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dc.contributor.authorButtari, Brigitta
dc.contributor.authorProfumo, Elisabetta
dc.contributor.authorFacchiano, Francesco
dc.contributor.authorOzturk, Elif Inci
dc.contributor.authorSegoni, Luca
dc.contributor.authorSaso, Luciano
dc.contributor.authorRiganò, Rachele
dc.date.accessioned2019-12-16T10:09:25Z
dc.date.available2019-12-16T10:09:25Z
dc.date.issued2013
dc.identifier.issn1942-0900
dc.identifier.urihttps://doi.org/10.1155/2013/574029
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725714/
dc.identifier.urihttp://hdl.handle.net/11655/19900
dc.description.abstractAdvanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to self-antigens. Previous findings suggest that AGE and its receptor RAGE may be involved in the pathogenesis of autoimmune reactions through dendritic cell (DC) activation. The aim of this study was to investigate whether resveratrol, a polyphenolic antioxidant compound with tolerogenic effects on DCs, was able to counteract the mechanisms triggered by AGE/RAGE interaction on DCs. By immunochemical and cytofluorimetric assays, we demonstrated that in vitro pretreatment of human monocyte-derived DCs with resveratrol prevents DC activation in response to glucose-treated albumin (AGE-albumin). We found that resveratrol exerts an inhibitory effect on DC surface maturation marker and RAGE up-regulation in response to AGE-albumin. It also inhibited proinflammatory cytokine expression, allostimulatory ability upregulation, mitogen-activated protein (MAP) kinases, and NF-κB activation in AGE-albumin-stimulated DCs. We suggest that resveratrol, by dismantling AGE/RAGE signaling on DCs may prevent or reduce increased reactivity to self-molecules in aging.
dc.relation.isversionof10.1155/2013/574029
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleResveratrol Prevents Dendritic Cell Maturation In Response To Advanced Glycation End Products
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalOxidative Medicine and Cellular Longevity
dc.contributor.departmentFarmakoloji
dc.identifier.volume2013
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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