dc.contributor.author | Abdel-Rahman, Rehab F. | |
dc.contributor.author | Soliman, Gamal A. | |
dc.contributor.author | Yusufoglu, Hasan S. | |
dc.contributor.author | Tatli-Cankaya, Irem | |
dc.contributor.author | Alqasoumi, Saleh I. | |
dc.contributor.author | Anul, Serap Arabci | |
dc.contributor.author | Akaydin, Galip | |
dc.date.accessioned | 2019-12-16T10:09:22Z | |
dc.date.available | 2019-12-16T10:09:22Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1596-5996 | |
dc.identifier.uri | https://doi.org/10.4314/tjpr.v14i10.13 | |
dc.identifier.uri | http://hdl.handle.net/11655/19893 | |
dc.description.abstract | Purpose: To evaluate the acticonvulsant activity of Cichorium intybus (C. intybus) and Taraxacum serotinum (T. serotinum) in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- and strychnine nitrate (STN) - induced seizure models in rats. Methods: For each model, 8 groups of Swiss albino rats (n=10) were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd - 5th were treated with C. intybus ethanol extract (125, 250 and 500 mg/kg); and 6th - 8th treated with T. serotinum extract (125, 250 and 500 mg/kg). After 30 min of administration, the rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Anticonvulsant activity was confirmed by abolition of hind limb tonic extension (HLTE) in MES test and by measuring the latency to PTZ or STN-induced threshold seizures, and the duration of seizures in the rats. Results: In MES model, 500 mg/kg of C. intybus and T. serotinum resulted in complete abolition of HLTE in 70 and 50 % of the rats, respectively, compared to 80 % in diazepam-medicated animals. Both extracts at 500 mg/kg prolonged latency to seizure onset in PTZ model to 144.7 and 114.7 s, respectively (vs 55.2 s in control group; p < 0.05). Both extracts failed to protect rats against STN-induced seizures. Conclusion: C. intybus and T. serotinum possess anticonvulsant effect as they both abolish HLTE induced by MES and delay the latency of seizures produced by PTZ. | |
dc.language.iso | en | |
dc.publisher | Pharmacotherapy Group | |
dc.relation.isversionof | 10.4314/tjpr.v14i10.13 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Pharmacology & Pharmacy | |
dc.title | Potential Anticonvulsant Activity of Ethanol Extracts of Cichorium Intybus and Taraxacum Serotinum in Rats | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Tropical Journal Of Pharmaceutical Research | |
dc.contributor.department | Farmasötik Botanik | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1829 | |
dc.identifier.endpage | 1835 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |