dc.contributor.author | Soylu, B.G | |
dc.contributor.author | Özbey, S | |
dc.contributor.author | Aydin, A. | |
dc.date.accessioned | 2019-12-13T06:35:44Z | |
dc.date.available | 2019-12-13T06:35:44Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2014.10.080 | |
dc.identifier.uri | http://hdl.handle.net/11655/18599 | |
dc.description.abstract | Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34,36,37,38-41) were synthesized and evaluated initially for their cytotoxic activities on liver Huh7, breast T47D and colon HCT116 carcinoma cells. N-6-(4-Trifluoromethylphenyl)piperazine derivative (17) and its 9-(p-toluene-sulfonyI)/9-cyclopentyl analogues (28, 36) had promising cytotoxic activities. Compounds 17, 28 and 36 were further analysed for their cytotoxicity in a panel of a liver cancer cell lines. The compound 36 had better cytotoxic activities (IC50 <= 1 mu M) than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells. Cytotoxicity induced by 36 was later identified as senescence associated cell death by SA-beta-Gal assay. (C) 2014 Elsevier Masson SAS. All rights reserved. | |
dc.language.iso | en | |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier | |
dc.relation.isversionof | 10.1016/j.ejmech.2014.10.080 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Pharmacology & Pharmacy | |
dc.title | Synthesis of Novel Substituted Purine Derivatives and Identification of the Cell Death Mechanism | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | European Journal Of Medicinal Chemistry | |
dc.contributor.department | Fizik Mühendisliği | |
dc.identifier.volume | 89 | |
dc.identifier.startpage | 701 | |
dc.identifier.endpage | 720 | |
dc.description.index | WoS | |