dc.contributor.author | Tonyali, Senol | |
dc.contributor.author | Ates, Deniz | |
dc.contributor.author | Akbiyik, Filiz | |
dc.contributor.author | Kankaya, Duygu | |
dc.contributor.author | Baydar, Dilek | |
dc.contributor.author | Ergen, Ali | |
dc.date.accessioned | 2019-12-12T06:48:16Z | |
dc.date.available | 2019-12-12T06:48:16Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1899-5276 | |
dc.identifier.uri | https://doi.org/10.17219/acem/69231 | |
dc.identifier.uri | http://hdl.handle.net/11655/17084 | |
dc.description.abstract | Background. Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a challenging disease, affecting thousands of people all around the world, especially women. Although there have been numerous theories regarding IC/BPS etiology, the physiopathology of the disease still remains unclear and there is a lack of certain treatment. Objectives. The aim of the study was to assess the role of nerve fibers and nerve growth factor (NGF) in the etiopathogenesis of IC/BPS symptoms by demonstrating if there is a correlation between urine NGF levels, amount of peripheral nerves in bladder mucosa and symptom severity. Material and methods. A prospective clinical study was conducted with 15 IC/BPS patients and 18 controls. Urine NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). Bladder punch biopsies were obtained from 15 IC/BPS patients and 9 controls. Immunohistochemistry was performed for S-100 to highlight peripheral nerve twigs in bladder mucosa. The O'Leary-Sant Interstitial Cystitis Symptom and Problem Index (OSICSPI) was used to assess symptom severity and effects of the disease on the patients' life. Results. NGF normalized to urine creatinine (NGF/Cr) levels in IC/BPS patients were significantly higher than in controls, 0.34 +/- 0.22 and 0.09 +/- 0.08 pg/mL: mg/dL, respectively (p < 0.001). The mean symptom score in IC patients was 12.27 +/- 2.4 (median: 12) and the mean problem score was 10.9 +/- 2.3 (median: 12). The mean mucosal nerve (S-100 stained) area in the IC/BPS group was significantly higher than in the controls, 2.53 +/- 1.90 vs 1.0 +/- 0.70, respectively (p = 0.018). In correlation analyses, the NGF/Cr level in IC/BPS patients was found significantly correlated with the O'Leary-Sant IC Symptom and Problem Index scores independently (p = 0.001 and p = 0.028, respectively). Conclusions. NGF seems to be a promising biomarker in IC/BPS. It may help clinicians in diagnoses and patient follow-up. Thus, unnecessary, expensive and invasive tests, interventions and treatments might be avoided. | |
dc.language.iso | en | |
dc.publisher | Wroclaw Medical Univ | |
dc.relation.isversionof | 10.17219/acem/69231 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Research & Experimental Medicine | |
dc.title | Urine Nerve Growth Factor (Ngf) Level, Bladder Nerve Staining And Symptom/Problem Scores In Patients With Interstitial Cystitis | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Advances In Clinical And Experimental Medicine | |
dc.contributor.department | Üroloji | |
dc.identifier.volume | 27 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 159 | |
dc.identifier.endpage | 163 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |