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dc.contributor.authorUlus, A. Tulga
dc.contributor.authorTuran, Nilufer N.
dc.contributor.authorOzyalcin, Sertan
dc.contributor.authorAydog, Gulden
dc.contributor.authorUlus, Fatma
dc.contributor.authorGoker, Hakan
dc.contributor.authorHaznedaroglu, Ibrahim C.
dc.date.accessioned2019-12-12T06:45:46Z
dc.date.available2019-12-12T06:45:46Z
dc.date.issued2011
dc.identifier.issn1300-7777
dc.identifier.urihttps://doi.org/10.5152/tjh.2011.55
dc.identifier.urihttp://hdl.handle.net/11655/16956
dc.description.abstractObjective: The aim of this study was to assess the surgical and histopathological hemostatic effects of topical Ankaferd blood stopper (ABS) on major arterial vessel injury related to elevated intra-arterial blood pressure in an experimental rabbit model. Materials and Methods: The study included 14 New Zealand rabbits. ABS was used to treat femoral artery puncture on 1 side in each animal and the other untreated side served as the control. Likewise, for abdominal aortic puncture, only 50% of the aortic injuries received topical liquid ABS and the others did not (control). The experiment was performed under conditions of normal arterial blood pressure and was repeated with a 50% increase in blood pressure. Histopathological analysis was performed in all of the studied animals. Results: Mean bleeding time in the control femoral arteries was 105.0 +/- 18.3 s, versus 51.4 +/- 9.8 s (p<0.05) in those treated with ABS. Mean blood loss from the punctured control femoral arteries was 5.0 +/- 1.5 mg and 1.6 +/- 0.4 mg from those treated with ABS (p<0.05). Histopathological examination of the damaged arterial structures showed that ABS induced red blood cell aggregates. Conclusion: ABS administered to experimental major arterial vessel injury reduced both bleeding time and blood loss under conditions of normal and elevated intra-arterial blood pressure. ABS-induced erythroid aggregation was prominent at the vascular tissue level. These findings will inform the design of future experimental and clinical studies on the anti-bleeding and vascular repairing effects of the novel hemostatic agent ABS. (Turk J Hematol 2011; 28: 206-12)
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.isversionof10.5152/tjh.2011.55
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHematology
dc.titleSurgical and Histopathological Effects of Topical Ankaferd (R) Hemostat on Major Arterial Vessel Injury Related to Elevated Intra-Arterial Blood Pressure
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Hematology
dc.contributor.departmentKalp ve Damar Cerrahisi
dc.identifier.volume28
dc.identifier.issue3
dc.identifier.startpage206
dc.identifier.endpage212
dc.description.indexWoS
dc.description.indexScopus


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