dc.contributor.author | Barentsz, M. W. | |
dc.contributor.author | Verkooijen, H. M. | |
dc.contributor.author | Pijnappel, R. M. | |
dc.contributor.author | Fernandez, M. A. | |
dc.contributor.author | Van Diest, P. J. | |
dc.contributor.author | Van der Pol, C. C. | |
dc.contributor.author | Witkamp, A. J. | |
dc.contributor.author | Hobbelink, M. G. G. | |
dc.contributor.author | Sever, A. R. | |
dc.contributor.author | Van den Bosch, M. A. A. J. | |
dc.date.accessioned | 2019-12-12T06:45:11Z | |
dc.date.available | 2019-12-12T06:45:11Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1743-9191 | |
dc.identifier.uri | https://doi.org/10.1016/j.ijsu.2014.12.019 | |
dc.identifier.uri | http://hdl.handle.net/11655/16922 | |
dc.description.abstract | Introduction: Our aim was to evaluate the development of microbubble-enhanced sentinel lymph node (SLN) localization with placement of an I-125 seed in breast cancer patients as a potential alternative for SLN localization with nanocolloid. The study is conducted and reported following the IDEAL recommendations for evaluation of a new technique at Stage 2a (Prospective Development Study). Methods: Fourteen consecutive patients with 15 lesions underwent microbubble-enhanced SLN localization with placement of an I-125 seed after the standard SLN localization (nanocolloid). We placed an I-125 seed within or near the SLN following its identification using intradermally injected microbubbles. The SLN was excised guided by nanocolloid and the SLN containing the I-125 seed was searched for. All technical modifications are described and standardized outcomes measured. Results: Twelve (80%) microbubble procedures with I-125 seed placements were technically successful. In three cases no microbubble-enhancing lymph node could be detected. Intraoperatively, we found nine I-125 seeds within 0.5 cm of the nanocolloid confirmed SLN. One I-125 seed was found next to a non-SLN and two I-125 seeds were not near any lymph node. Overall, the procedure was successful in 60% (9 out of 15) of the cases. Conclusion: Given the low success rate, we conclude that microbubble-enhanced SLN is not a viable alternative to the standard SLN procedure. Modifications to this technique did not improve its performance. Planned study (NTR3690 http://www.trialregister.nl/trialreg/admin/rctview.asp? TC = 3690) was stopped early due to this conclusion and results reported in order to provide a full and transparent record of the evolution of technique. (C) 2015 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. | |
dc.language.iso | en | |
dc.publisher | Elsevier Science Bv | |
dc.relation.isversionof | 10.1016/j.ijsu.2014.12.019 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Surgery | |
dc.title | Sentinel Lymph Node Localization with Contrast-Enhanced Ultrasound and An I-125 Seed: An Ideal Prospective Development Study | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | International Journal Of Surgery | |
dc.contributor.department | Genel Cerrahi | |
dc.identifier.volume | 14 | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 6 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |