dc.contributor.author | Mermerkaya, Musa Uğur | |
dc.contributor.author | Doral, Mahmut Nedim | |
dc.contributor.author | Karaaslan, Fatih | |
dc.contributor.author | Huri, Gazi | |
dc.contributor.author | Karacavuş, Seyhan | |
dc.contributor.author | Kaymaz, Burak | |
dc.contributor.author | Alkan, Erkan | |
dc.date.accessioned | 2019-12-12T06:45:07Z | |
dc.date.available | 2019-12-12T06:45:07Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1749-799X | |
dc.identifier.uri | https://doi.org/10.1186/s13018-016-0393-y | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855359/ | |
dc.identifier.uri | http://hdl.handle.net/11655/16917 | |
dc.description.abstract | Background An unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect® (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place. The aim of this study was to compare osteoblastic activity by the use of scintigraphic methods in defective rabbit tibias during early-phase bone healing with or without a hyaluronan-based mesh. Methods Two groups (A and B) of New Zealand albino rabbits were used; each group included 10 animals. Operations on all rabbits were performed under general anesthesia. We also resected 10-mm bone segments from each animal’s tibial diaphysis. After resection, tibias with defects were fixed using Kirschner wires. In group A, no hyaluronan-based mesh was used. In group B, tibial segmental defects were enclosed with a hyaluronan-based mesh. The rabbits were followed up for 4 weeks postoperatively, after which bone scintigraphic studies were performed on each animal to detect and compare osteoblastic activity. Results The mean count in the fracture side of the hyaluronan-based mesh group was significantly higher compared to that of the group A (p = 0.019). However, there was no significant difference between group B and control rabbits with respect to the mean count on the intact bone side (p = 0.437). The bone defect (fracture)/intact bone mean count ratio was significantly higher in group B compared to group A (p = 0.008). Conclusions A hyaluronan-based mesh plays a role in promoting osteoblastic activity. Hyalonect® is suitable for restoring tissue continuity whenever the periosteal membrane is structurally impaired or inadequate. Our results demonstrated that, during early-phase bone healing, osteoblastic activity was increased in bone defect sites when a hyaluronan-based mesh was also used. The most important aspect of this study concerns its scintigraphy-based design. This study is the first to use a scintigraphic method to demonstrate the effectiveness of hyaluronic acid-based material for bone healing. | |
dc.relation.isversionof | 10.1186/s13018-016-0393-y | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Scintigraphic Evaluation of the Osteoblastic Activity of Rabbit Tibial Defects After Hyaff11 Membrane Application | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal of Orthopaedic Surgery and Research | |
dc.contributor.department | Ortopedi ve Travmatoloji | |
dc.identifier.volume | 11 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |
dc.description.index | Scopus | |