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dc.contributor.authorMarazita, ML
dc.contributor.authorMurray, JC
dc.contributor.authorLidral, AC
dc.contributor.authorArcos-Burgos, M
dc.contributor.authorCooper, ME
dc.contributor.authorGoldstein, T
dc.contributor.authorMaher, BS
dc.contributor.authorDaack-Hirsch, S
dc.contributor.authorSchultz, R
dc.contributor.authorMansilla, MA
dc.contributor.authorField, LL
dc.contributor.authorLiu, Y
dc.contributor.authorPrescott, N
dc.contributor.authorMalcolm, S
dc.contributor.authorWinter, R
dc.contributor.authorRay, A
dc.contributor.authorMoreno, L
dc.contributor.authorValencia, C
dc.contributor.authorNeiswanger, K
dc.contributor.authorWyszynski, DF
dc.contributor.authorBailey-Wilson, JE
dc.contributor.authorAlbacha-Hejazi, H
dc.contributor.authorBeaty, TH
dc.contributor.authorMcIntosh, I
dc.contributor.authorHetmanski, JB
dc.contributor.authorTuncbilek, G
dc.contributor.authorEdwards, M
dc.contributor.authorHarkin, L
dc.contributor.authorScott, R
dc.contributor.authorRoddick, LG
dc.date.accessioned2019-12-12T06:43:03Z
dc.date.available2019-12-12T06:43:03Z
dc.date.issued2004
dc.identifier.issn0002-9297
dc.identifier.urihttps://doi.org/10.1086/422475
dc.identifier.urihttp://hdl.handle.net/11655/16780
dc.description.abstractIsolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P from seven diverse populations (2,551 genotyped individuals) revealed CL/P genes in six chromosomal regions, including a novel region at 9q21 (heterogeneity LOD score [HLOD] = 6.6). In addition, meta-analyses with the addition of results from 186 more families ( six populations; 1,033 genotyped individuals) showed genomewide significance for 10 more regions, including another novel region at 2q32-35 (P = .0004). These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder.
dc.language.isoen
dc.publisherUniv Chicago Press
dc.relation.isversionof10.1086/422475
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGenetics & Heredity
dc.titleMeta-Analysis Of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes With Novel Loci On 9Q21 And 2Q32-35
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalAmerican Journal Of Human Genetics
dc.contributor.departmentPlastik, Rekonstrüktif ve Estetik Cerrahi
dc.identifier.volume75
dc.identifier.issue2
dc.identifier.startpage161
dc.identifier.endpage173
dc.description.indexWoS
dc.description.indexScopus


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