dc.contributor.author | Marazita, ML | |
dc.contributor.author | Murray, JC | |
dc.contributor.author | Lidral, AC | |
dc.contributor.author | Arcos-Burgos, M | |
dc.contributor.author | Cooper, ME | |
dc.contributor.author | Goldstein, T | |
dc.contributor.author | Maher, BS | |
dc.contributor.author | Daack-Hirsch, S | |
dc.contributor.author | Schultz, R | |
dc.contributor.author | Mansilla, MA | |
dc.contributor.author | Field, LL | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Prescott, N | |
dc.contributor.author | Malcolm, S | |
dc.contributor.author | Winter, R | |
dc.contributor.author | Ray, A | |
dc.contributor.author | Moreno, L | |
dc.contributor.author | Valencia, C | |
dc.contributor.author | Neiswanger, K | |
dc.contributor.author | Wyszynski, DF | |
dc.contributor.author | Bailey-Wilson, JE | |
dc.contributor.author | Albacha-Hejazi, H | |
dc.contributor.author | Beaty, TH | |
dc.contributor.author | McIntosh, I | |
dc.contributor.author | Hetmanski, JB | |
dc.contributor.author | Tuncbilek, G | |
dc.contributor.author | Edwards, M | |
dc.contributor.author | Harkin, L | |
dc.contributor.author | Scott, R | |
dc.contributor.author | Roddick, LG | |
dc.date.accessioned | 2019-12-12T06:43:03Z | |
dc.date.available | 2019-12-12T06:43:03Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0002-9297 | |
dc.identifier.uri | https://doi.org/10.1086/422475 | |
dc.identifier.uri | http://hdl.handle.net/11655/16780 | |
dc.description.abstract | Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P from seven diverse populations (2,551 genotyped individuals) revealed CL/P genes in six chromosomal regions, including a novel region at 9q21 (heterogeneity LOD score [HLOD] = 6.6). In addition, meta-analyses with the addition of results from 186 more families ( six populations; 1,033 genotyped individuals) showed genomewide significance for 10 more regions, including another novel region at 2q32-35 (P = .0004). These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder. | |
dc.language.iso | en | |
dc.publisher | Univ Chicago Press | |
dc.relation.isversionof | 10.1086/422475 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Genetics & Heredity | |
dc.title | Meta-Analysis Of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes With Novel Loci On 9Q21 And 2Q32-35 | |
dc.type | info:eu-repo/semantics/article | |
dc.relation.journal | American Journal Of Human Genetics | |
dc.contributor.department | Plastik, Rekonstrüktif ve Estetik Cerrahi | |
dc.identifier.volume | 75 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 161 | |
dc.identifier.endpage | 173 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |