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dc.contributor.authorAyhan, Ayse
dc.contributor.authorYasui, Wataru
dc.contributor.authorYokozaki, Hiroshi
dc.contributor.authorSeto, Masao
dc.contributor.authorUeda, Ryuzo
dc.contributor.authorTahara, Eiichi
dc.date.accessioned2019-12-12T06:42:53Z
dc.date.available2019-12-12T06:42:53Z
dc.date.issued1994
dc.identifier.issn0910-5050
dc.identifier.urihttps://doi.org/10.1111/j.1349-7006.1994.tb02400.x
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919525/
dc.identifier.urihttp://hdl.handle.net/11655/16767
dc.description.abstractThe loss of heterozygosity (LOH) at the bcl‐2 gene locus and the expression of the bcl‐2 gene were examined in gastric and colorectal carcinoma cell lines and carcinoma tissues. LOH at the bcl‐2 locus was detected in 24% (4/17) of gastric and 60% (6/10) of colonic carcinomas, all of which were well differentiated adenocarcinomas, whereas LOH was not seen in poorly differentiated ones. On the other hand, 24% (5/21) of poorly differentiated stomach cancers overexpressed bcl‐2 gene, whereas no overexpression was detected in well differentiated stomach cancer. Three gastric and three colorectal carcinoma cell lines, all of which were derived from poorly differentiated adenocarcinomas, expressed considerable levels of bcl‐2 mRNA and protein. These results suggest that LOH at the bcl‐2 locus is frequently associated with well differentiated adenocarcinomas of the stomach and colon, and bcl‐2 overexpression has implications for the development of poorly differentiated adenocarcinomas of the gastrointestinal tract.
dc.relation.isversionof10.1111/j.1349-7006.1994.tb02400.x
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLoss of Heterozygosity at the Bcl‐2 Gene Locus and Expression of Bcl‐2 in Human Gastric and Colorectal Carcinomas
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJapanese Journal of Cancer Research : Gann
dc.contributor.departmentTıbbi Patoloji
dc.identifier.volume85
dc.identifier.issue6
dc.identifier.startpage584
dc.identifier.endpage591
dc.description.indexPubMed
dc.description.indexWoS


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