dc.contributor.author | Cowan, Morgan | |
dc.contributor.author | Springer, Simeon | |
dc.contributor.author | Nguyen, Doreen | |
dc.contributor.author | Taheri, Diana | |
dc.contributor.author | Guner, Gunes | |
dc.contributor.author | Rodriguez, Maria Angelica Mendoza | |
dc.contributor.author | Wang, Yuxuan | |
dc.contributor.author | Kinde, Isaac | |
dc.contributor.author | VandenBussche, Christopher J. | |
dc.contributor.author | Olson, Matthew T. | |
dc.contributor.author | Cunha, Isabela | |
dc.contributor.author | Fujita, Kazutoshi | |
dc.contributor.author | Ertoy, Dilek | |
dc.contributor.author | Bivalacqua, Trinity J. | |
dc.contributor.author | Kinzler, Kenneth | |
dc.contributor.author | Vogelstein, Bert | |
dc.contributor.author | Netto, George J. | |
dc.contributor.author | Papadopoulos, Nickolas | |
dc.date.accessioned | 2019-12-12T06:41:59Z | |
dc.date.available | 2019-12-12T06:41:59Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0893-3952 | |
dc.identifier.uri | https://doi.org/10.1038/modpathol.2016.53 | |
dc.identifier.uri | http://hdl.handle.net/11655/16691 | |
dc.description.abstract | TERT promoter mutations (TERT-mut) are detectable in the majority of urothelial carcinomas. The detection of TERT-mut in urine is under investigation as a potential urine-based molecular-screening assay for bladder cancer. A small but significant number of bladder carcinomas are pure squamous cell carcinoma. We sought to assess the incidence of TERT-mut in squamous cell carcinoma of the urinary bladder. A retrospective search of the institutional pathology archives yielded 15 cystectomy specimens performed for squamous cell carcinoma (2000-2014). Histologic slides were reviewed by a senior urologic pathologist to confirm the diagnosis and select a representative formalin-fixed paraffin-embedded tissue block for mutational analysis. All cases yielded adequate material for DNA analysis. Sequencing for TERT-mut was performed using previously described SafeSeq technique. We detected TERT-mut in 12/15 (80%) of bladder squamous cell carcinomas. TERT promoter mutations, commonly found in conventional urothelial carcinoma, are also highly prevalent in urinary bladder squamous cell carcinoma suggesting a common tumorigenesis and potential utility as a molecular urine-based-screening assay. | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.relation.isversionof | 10.1038/modpathol.2016.53 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Pathology | |
dc.title | High Prevalence Of Tert Promoter Mutations In Primary Squamous Cell Carcinoma Of The Urinary Bladder | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Modern Pathology | |
dc.contributor.department | Tıbbi Patoloji | |
dc.identifier.volume | 29 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 511 | |
dc.identifier.endpage | 515 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |