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dc.contributor.authorDadaci, Mehmet
dc.contributor.authorKaragulle, Nimet
dc.contributor.authorSonmez, Erhan
dc.contributor.authorDadaci, Zeynep
dc.contributor.authorIsci, Evren Tevfik
dc.contributor.authorInce, Bilsev
dc.contributor.authorVargel, Ibrahim
dc.contributor.authorPiskin, Erhan
dc.contributor.authorErk, Ali Yucel
dc.date.accessioned2019-12-12T06:41:04Z
dc.date.available2019-12-12T06:41:04Z
dc.date.issued2016
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1412-110
dc.identifier.urihttp://hdl.handle.net/11655/16639
dc.description.abstractBackground/aim: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-epsilon-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. Materials and methods: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. The numbers of myelinated axons in the cross-sections of the nerves were compared between the groups. Results: Macroscopically, all nerve coaptations were intact and biodegradation was detected in nerve conduits. Electromyographic assessment and count of myelinated axons in the cross-sections of the nerves displayed the best regeneration in the nerve graft group (P < 0.001) and similar results were obtained in the PLCL and EC nerve conduit groups (P = 0.79). Light and electron microscopy studies demonstrated nerve regeneration in both nerve conduit groups. Conclusion: EC nerve conduits and PLCL nerve conduits yielded similar results and may be alternatives to nerve grafts as they biodegrade.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1412-110
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleEvaluation Of The Effectiveness Of Biodegradable Electrospun Caprolactone And Poly(Lactic Acid-E-Caprolactone) Nerve Conduits For Peripheral Nerve Regenerations In A Rat Sciatic Nerve Defect Modeltr_en
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentPlastik, Rekonstrüktif ve Estetik Cerrahi
dc.identifier.volume46
dc.identifier.issue2
dc.identifier.startpage539
dc.identifier.endpage548
dc.description.indexWoS
dc.description.indexScopus


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