dc.contributor.author | Falkmarken, Neslihan H. Dikmenoglu | |
dc.contributor.author | Arihan, Okan | |
dc.contributor.author | Iskit, Alper B. | |
dc.date.accessioned | 2019-12-12T06:27:20Z | |
dc.date.available | 2019-12-12T06:27:20Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.uri | https://doi.org/10.3906/sag-1607-19 | |
dc.identifier.uri | http://hdl.handle.net/11655/16457 | |
dc.description.abstract | Background/aim: Septic shock is an important health problem that vastly alters cardiovascular and hemodynamic status. Increased production of nitric oxide (NO) and endothelin is a counterpart of this endotoxemic state. This study was conducted to test the hypothesis that nonselective NO synthesis blocker (L-NAME), inducible NO synthesis blocker (L-canavanine), or endothelin receptor antagonist (bosentan) will reverse the effects of sepsis on hemorheological parameters. Materials and methods: Forty-eight male Sprague-Dawley rats were used in 8 groups: saline (control), endotoxin, bosentan, L-NAME, L-canavanine, endotoxin + bosentan, endotoxin + L-NAME, and endotoxin + L-canavanine. Blood was withdrawn at the 4th hour of endotoxemic state. Erythrocyte deformability and erythrocyte aggregation were determined by laser-assisted optical rotational cell analyzer at 37 degrees C. Plasma viscosity (mPa.s) was measured by a cone-plate viscometer with 0.5 mL of plasma. Results: Endotoxin administration significantly increased aggregation half-time and lowered erythrocyte aggregation amplitude and aggregation index compared to the control, indicating a slower and weaker aggregation pattern. L-NAME and L-canavanine alleviated the effects of endotoxin on erythrocyte aggregation without altering the values in the control animals. However, bosentan did not perform such a restoration. Conclusion: This finding suggests that these restoration effects of the blockers occur via their modulation of nitric oxide synthesis rather than through the endothelin pathway. | |
dc.language.iso | en | |
dc.publisher | Tubitak Scientific & Technical Research Council Turkey | |
dc.relation.isversionof | 10.3906/sag-1607-19 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | General & Internal Medicine | |
dc.title | Comparison Of Endothelin And Nitric Oxide Synthase Blockers On Hemorheological Parameters In Endotoxemic Rats | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Medical Sciences | |
dc.contributor.department | Fizyoloji | |
dc.identifier.volume | 47 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 1045 | |
dc.identifier.endpage | 1052 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |