Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus Fumigatus

View/Open
Date
2015
Author
van der Linden, J.W.M.
Arendrup, M.C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P.M.
Chryssanthou, E.
Mellado, E.
Kidd, S.E.
Tortorano, A.M.
Dannaoui, E.
Gaustad, P.
Baddley, J.W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C.B.
Denning, D.W.
Pasqualotto, A.C.
Kibbler, C.
Arikan-Akdagli, S.
Andes, D.
Meletiadis, J.
Naumiuk, L.
Nucci, M.
Melchers, W.J.G.
Verweij, P.E.
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
URI
https://doi.org/10.3201/eid2106.140717
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451897/
http://hdl.handle.net/11655/16322
xmlui.mirage2.itemSummaryView.Collections