Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus Fumigatus

Göster/Aç
Tarih
2015
Yazar
van der Linden, J.W.M.
Arendrup, M.C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P.M.
Chryssanthou, E.
Mellado, E.
Kidd, S.E.
Tortorano, A.M.
Dannaoui, E.
Gaustad, P.
Baddley, J.W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C.B.
Denning, D.W.
Pasqualotto, A.C.
Kibbler, C.
Arikan-Akdagli, S.
Andes, D.
Meletiadis, J.
Naumiuk, L.
Nucci, M.
Melchers, W.J.G.
Verweij, P.E.
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Özet
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
Bağlantı
https://doi.org/10.3201/eid2106.140717
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451897/
http://hdl.handle.net/11655/16322
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