dc.contributor.author | Donmez, Melahat | |
dc.contributor.author | Uysal, Bulent | |
dc.contributor.author | Poyrazoglu, Yavuz | |
dc.contributor.author | Er Oztas, Yesim | |
dc.contributor.author | Turker, Turker | |
dc.contributor.author | Kaldirim, Umit | |
dc.contributor.author | Korkmaz, Ahmet | |
dc.date.accessioned | 2019-12-12T06:25:41Z | |
dc.date.available | 2019-12-12T06:25:41Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.uri | https://doi.org/10.3906/sag-1308-48 | |
dc.identifier.uri | http://hdl.handle.net/11655/16311 | |
dc.description.abstract | Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity. Materials and methods: Twenty-four Sprague-Dawley rats were divided equally into 3 experimental groups: sham group, APAP group, and APAP + 3-AB group. In the experimental treatment groups APAP was administered orally at 1 g/kg and, in the APAP + 3-AB group, 3-AB was administered intraperitoneally at a dose of 20 mg/kg exactly 1 h after APAP treatment. Surviving animals were euthanized 48 h after initial APAP administration. Blood samples and liver tissues were collected for histopathological and biochemical analysis. Results: A panel of oxidative stress parameters, as well as serum aspartate aminotransferase, alanine aminotransferase, neopterin, and nitrite/nitrate and histological injury scores, were significantly reduced among the APAP + 3-AB treatment group relative to the group treated with APAP alone (P < 0.05, APAP vs. APAP + 3-AB). Conclusion: The present study demonstrates that 3-AB inhibited APAP-induced hepatic injury and reduced neopterin levels. Results of the present study indicate that PARP inhibitors may be an effective adjuvant therapy resulting in improved outcomes in APAP-induced hepatotoxicity. | |
dc.language.iso | en | |
dc.publisher | Tubitak Scientific & Technical Research Council Turkey | |
dc.relation.isversionof | 10.3906/sag-1308-48 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | General & Internal Medicine | |
dc.title | Parp Inhibition Prevents Acetaminophen-Induced Liver Injury and Increases Survival Rate in Rats | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Medical Sciences | |
dc.contributor.department | Tıbbi Biyokimya | |
dc.identifier.volume | 45 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 18 | |
dc.identifier.endpage | 26 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |