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dc.contributor.authorUgras, Akin
dc.contributor.authorGuzel, Elif
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorKaya, Ibrahim
dc.contributor.authorDikici, Fatih
dc.contributor.authorDemirbas, Emrah
dc.contributor.authorCetinus, Ercan
dc.date.accessioned2019-12-12T06:24:50Z
dc.date.available2019-12-12T06:24:50Z
dc.date.issued2013
dc.identifier.issn1306-696X
dc.identifier.urihttps://doi.org/10.5505/tjtes.2013.03256
dc.identifier.urihttp://hdl.handle.net/11655/16212
dc.description.abstractBACKGROUND The aim of this study is to determine whether glucosamine-sulfate has any effects on bone-healing. METHODS A unilateral fracture was created in the tibia of sixty-one female rats. Rats were given no drug or 230 mg/kg glucosamine- sulfate daily. Fractures were analyzed during the first, second and fourth weeks after creation of fracture. Quantitative measurement for new bone formation and osteoblast lining were determined histologically. Semiquantitative score for fracture healing was used for histomorphometric analyses. Bridging bone formation was assessed radiographically. RESULTS New bone formation and osteoblast lining were significantly higher in glucosamine-treated group at week 1. Surrounding connective tissue was more cellular and vascular, and the newly formed bone trabecules were present in greater amounts in glucosamine-treated group, compared to control group at week 1 and 4. But radiologically, the control group had better scores than that of the glucosamine- treated group at week 4. CONCLUSION These data demonstrate that daily glucosamine-sulfate administration accelerates early phase of fracture repair in the rat tibia, with increased new bone formation and osteoblast lining histologically, but radiologic bone union is not favored on radiographs.
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.isversionof10.5505/tjtes.2013.03256
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEmergency Medicine
dc.titleGlucosamine-Sulfate On Fracture Healing
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgery
dc.contributor.departmentHistoloji ve Embriyoloji
dc.identifier.volume19
dc.identifier.issue1
dc.identifier.startpage8
dc.identifier.endpage12
dc.description.indexWoS
dc.description.indexScopus


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