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Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia
(Sage Publications Inc, 1999)
Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy ...
Mechanisms Of Motor Dysfunction After Transient Mca Occlusion - Persistent Transmission Failure In Cortical Synapses Is A Major Determinant
(Lippincott Williams & Wilkins, 1998)
Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thrombolytic therapy may be due to an unsatisfactory restoration of synaptic activity within cortex and/or blockade of electrical ...
Role of Endothelial Nitric Oxide Generation and Peroxynitrite Formation in Reperfusion Injury After Focal Cerebral Ischemia
(Lippincott Williams & Wilkins, 2000)
Background and Purpose-Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on ...