Browsing Tıp Fakültesi by Publisher "Pergamon-Elsevier Science Ltd"

Now showing items 1-6 of 6

    • Animal Models of Gene-Environment Interaction in Schizophrenia: A Dimensional Perspective 

      Ayhan, Yavuz; McFarland, Ross; Pletnikov, Mikhail V. (Pergamon-Elsevier Science Ltd, 2016)
      Schizophrenia has long been considered as a disorder with multifactorial origins. Recent discoveries have advanced our understanding of the genetic architecture of the disease. However, even with the increase of identified ...

    • Blockade of Gaba Synthesis Only Affects Neural Excitability Under Activated Conditions in Rat Hippocampal Slices 

      Dericioglu, Nese; Garganta, Cheryl L.; Petroff, Ognen A.; Mendelsohn, Dara; Williamson, Anne (Pergamon-Elsevier Science Ltd, 2008)
      The primary goal of this study was to establish whether inhibition of GABA synthesis was sufficient to induce network hyperexcitability in a rat hippocampal slice model comparable to that seen with GABA receptor blockade. ...

    • Estrogen And Aging Affect Synaptic Distribution Of Phosphorylated Lim Kinase (Plimk) In Ca1 Region Of Female Rat Hippocampus 

      Yildirim, M.; Janssen, W. G. M.; Tabori, N. E.; Adams, M. M.; Yuen, G. S.; Akama, K. T.; McEwen, B. S.; Milner, T. A.; Morrison, J. H. (Pergamon-Elsevier Science Ltd, 2008)
      17 beta-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic ...

    • Mutation In Tor1Aip1 Encoding Lap1B In A Form Of Muscular Dystrophy: A Novel Gene Related To Nuclear Envelopathies 

      Kayman-Kurekci, Gulsum; Talim, Beril; Korkusuz, Petek; Sayar, Nilufer; Sarioglu, Turkan; Oncel, Ibrahim; Sharafi, Parisa; Gundesli, Hulya; Balci-Hayta, Burcu; Purali, Nuhan; Serdaroglu-Oflazer, Piraye; Topaloglu, Haluk; Dincer, Pervin (Pergamon-Elsevier Science Ltd, 2014)
      We performed genome-wide homozygosity mapping and mapped a novel myopathic phenotype to chromosomal region 1q25 in a consanguineous family with three affected individuals manifesting proximal and distal weakness and atrophy, ...

    • Myophosphorylase (Pygm) Mutations Determined By Next Generation Sequencing In A Cohort From Turkey With Mcardle Disease 

      Inal-Gultekin, Guldal; Toptas-Hekimoglu, Bahar; Gormez, Zeliha; Gelisin, Ozlem; Durmus, Hacer; Erguner, Bekir; Demirci, Huseyin; Sagiroglu, Mahmut S.; Parman, Yesim; Deymeer, Feza; Yilmaz-Aydogan, Hulya; Pence, Sadrettin; Bekircan-Kurt, Can Ebru; Tan, Ersin; Erdem-Ozdamar, Sevim; Ustek, Duran; Giger, Urs; Ozturk, Oguz; Serdaroglu-Oflazer, Piraye (Pergamon-Elsevier Science Ltd, 2017)
      This study aimed to identify PYGM mutations in patients with McArdle disease from Turkey by next generation sequencing (NGS). Genomic DNA was extracted from the blood of the McArdle patients (n = 67) and unrelated healthy ...

    • Social Achievement Goals, Needs Satisfaction, And Coping Among Adolescents 

      Michou, Aikaterini; Mouratidis, Athanasios; Ersoy, Evren; Ugur, Hasan (Pergamon-Elsevier Science Ltd, 2016)
      In a sample of Turkish adolescents (N = 1614), we investigated whether pursuing social demonstration-approach goals (to attain popularity), next to social development goals (to cultivate meaningful relationships), explains ...