dc.contributor.author | Gultekin, Melis | |
dc.contributor.author | Cengiz, Mustafa | |
dc.contributor.author | Sezen, Duygu | |
dc.contributor.author | Zorlu, Faruk | |
dc.contributor.author | Yildiz, Ferah | |
dc.contributor.author | Yazici, Gozde | |
dc.contributor.author | Hurmuz, Pervin | |
dc.contributor.author | Ozyigit, Gokhan | |
dc.contributor.author | Akyol, Fadil | |
dc.contributor.author | Gurkaynak, Murat | |
dc.date.accessioned | 2019-12-10T11:30:52Z | |
dc.date.available | 2019-12-10T11:30:52Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1533-0346 | |
dc.identifier.uri | https://doi.org/10.1177/1533034616655952 | |
dc.identifier.uri | http://hdl.handle.net/11655/15820 | |
dc.description.abstract | Background: This study aimed to evaluate the efficacy and safety of hypofractionated stereotactic radiotherapy for reirradiation of recurrent pediatric tumors. Methods and Materials: The study included 23 pediatric patients who were reirradiated using hypofractionated stereotactic radiotherapy in the radiation oncology department between January 2008 and November 2013. In total, 33 tumors were treated-27 (82%) cranial and 6 (18%) extracranial. Hypofractionated stereotactic radiotherapy was administered due to recurrent disease in 31 (94%) tumors and residual disease in 2 (6%) tumors. The median total dose was 25 Gy (range: 15-40 Gy), and the median follow-up was 20 months (range: 2-68 months). Results: The 1-year and 2-year local control rates in the entire study population were 42% and 31%, respectively. The median local control time was 11 months (range: 0-54 months) following hypofractionated stereotactic radiotherapy. The patients with tumor response after hypofractionated stereotactic radiotherapy had significantly longer local control than the patients with post-hypofractionated stereotactic radiotherapy tumor progression (21 vs 3 months, P < .001). Tumor volume <1.58 cm(3) was correlated (not significantly) with better local control (23 vs 7 months, P = .064). Conclusion: Reirradiation of pediatric tumors using hypofractionated stereotactic radiotherapy is a safe and effective therapeutic approach. This treatment modality should be considered as a treatment option in selected pediatric patients. | |
dc.language.iso | en | |
dc.publisher | Sage Publications Inc | |
dc.relation.isversionof | 10.1177/1533034616655952 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Oncology | |
dc.title | Reirradiation of Pediatric Tumors Using Hypofractionated Stereotactic Radiotherapy | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Technology In Cancer Research & Treatment | |
dc.contributor.department | Radyasyon Onkolojisi | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 195 | |
dc.identifier.endpage | 202 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |