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dc.contributor.authorGaudin, Alice
dc.contributor.authorYemisci, Müge
dc.contributor.authorEroglu, Hakan
dc.contributor.authorLepêtre-Mouelhi, Sinda
dc.contributor.authorTurkoglu, Omer Faruk
dc.contributor.authorDönmez-Demir, Buket
dc.contributor.authorCaban, Seçil
dc.contributor.authorFevzi Sargon, Mustafa
dc.contributor.authorGarcia-Argote, Sébastien
dc.contributor.authorPieters, Grégory
dc.contributor.authorLoreau, Olivier
dc.contributor.authorRousseau, Bernard
dc.contributor.authorTagit, Oya
dc.contributor.authorHildebrandt, Niko
dc.contributor.authorLe Dantec, Yannick
dc.contributor.authorMougin, Julie
dc.contributor.authorValetti, Sabrina
dc.contributor.authorChacun, Hélène
dc.contributor.authorNicolas, Valérie
dc.contributor.authorDesmaële, Didier
dc.contributor.authorAndrieux, Karine
dc.contributor.authorCapan, Yilmaz
dc.contributor.authorDalkara, Turgay
dc.contributor.authorCouvreur, Patrick
dc.date.accessioned2019-12-10T11:26:00Z
dc.date.available2019-12-10T11:26:00Z
dc.date.issued2014
dc.identifier.issn1748-3387
dc.identifier.urihttps://doi.org/10.1038/nnano.2014.274
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351925/
dc.identifier.urihttp://hdl.handle.net/11655/15736
dc.description.abstractThere is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries. However, many drugs with potential neuropharmacological activity, like adenosine, are inefficient upon systemic administration because of their fast metabolisation and rapid clearance from the bloodstream. Here, we show that the conjugation of adenosine to the lipid squalene and the subsequent formation of nanoassemblies allow a prolonged circulation of this nucleoside, to provide neuroprotection in mouse stroke and rat spinal cord injury models. The animals receiving systemic administration of squalenoyl adenosine nanoassemblies showed a significant improvement of their neurologic deficit score in the case of cerebral ischaemia, and an early motor recovery of the hindlimbs in the case of spinal cord injury. Moreover, in vitro and in vivo studies demonstrated that the nanoassemblies were able to extend adenosine circulation and its interaction with the neurovascular unit. This paper shows, for the first time, that a hydrophilic and rapidly metabolised molecule like adenosine may become pharmacologically efficient owing to a single conjugation with the lipid squalene.
dc.relation.isversionof10.1038/nnano.2014.274
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSqualenoyl Adenosine Nanoparticles Provide Neuroprotection After Stroke And Spinal Cord Injury
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalNature nanotechnology
dc.contributor.departmentNöroloji
dc.identifier.volume9
dc.identifier.issue12
dc.identifier.startpage1054
dc.identifier.endpage1062
dc.description.indexPubMed
dc.description.indexWoS


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