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dc.contributor.authorAy, H
dc.contributor.authorArsava, EM
dc.contributor.authorSaribas, O
dc.date.accessioned2019-12-10T11:24:40Z
dc.date.available2019-12-10T11:24:40Z
dc.date.issued2002
dc.identifier.issn0039-2499
dc.identifier.urihttps://doi.org/10.1161/hs0102.101544
dc.identifier.urihttp://hdl.handle.net/11655/15661
dc.description.abstractBackground and Purpose-Creatine kinase-MB (CK-MB) increases in some patients with stroke, with no clear evidence of an acute coronary syndrome. Its elevations have been suggested to represent a biological marker for stroke-related myocardial injury. Troponin T has superior sensitivity and specificity to CK-MB in revealing minor myocardial injury. Therefore, we studied troponin T levels after stroke to determine whether troponin T increases in parallel to CK-MB. Methods-We made daily measurements of CK-MB, myoglobin, total creatine kinase (total CK), and troponin T levels up to day 5 in 32 patients with large hemispheric infarction and with no history of coronary heart disease. The daily enzyme levels were compared with those of a control group of 22 patients with neurological diseases other than stroke. Results-Serum CK-MB, myoglobin, and total CK levels were elevated above the cutoff value in 11, 26, and 20 patients with stroke, respectively. These enzyme levels gradually increased within the first 3 days and declined afterward. Troponin T did not exceed the reference range in any patients. One patient had elevated myoglobin and 3 had elevated total CK in the control group. The difference between groups was significant for CK-MB, myoglobin, and total CK at various time points. Conclusions-Troponin T, a more specific biochemical marker of myocardial injury, does not increase after stroke. Normal troponin T along with elevated CK-MB signifies that CK-MB is not the biological marker for myocytolysis. CK-MB elevations in stroke patients are likely to be noncardiac in origin.
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.isversionof10.1161/hs0102.101544
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & Neurology
dc.subjectCardiovascular System & Cardiology
dc.titleCreatine Kinase-Mb Elevation After Stroke Is Not Cardiac In Origin - Comparison With Troponin T Levels
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalStroke
dc.contributor.departmentNöroloji
dc.identifier.volume33
dc.identifier.issue1
dc.identifier.startpage286
dc.identifier.endpage289
dc.description.indexWoS
dc.description.indexScopus


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