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dc.contributor.authorStroes, Erik S.
dc.contributor.authorThompson, Paul D.
dc.contributor.authorCorsini, Alberto
dc.contributor.authorVladutiu, Georgirene D.
dc.contributor.authorRaal, Frederick J.
dc.contributor.authorRay, Kausik K.
dc.contributor.authorRoden, Michael
dc.contributor.authorStein, Evan
dc.contributor.authorTokgozoglu, Lale
dc.contributor.authorNordestgaard, Borge G.
dc.contributor.authorBruckert, Eric
dc.contributor.authorDe Backer, Guy
dc.contributor.authorKrauss, Ronald M.
dc.contributor.authorLaufs, Ulrich
dc.contributor.authorSantos, Raul D.
dc.contributor.authorHegele, Robert A.
dc.contributor.authorHovingh, G. Kees
dc.contributor.authorLeiter, Lawrence A.
dc.contributor.authorMach, Francois
dc.contributor.authorMaerz, Winfried
dc.contributor.authorNewman, Connie B.
dc.contributor.authorWiklund, Olov
dc.contributor.authorJacobson, Terry A.
dc.contributor.authorCatapano, Alberico L.
dc.contributor.authorChapman, M. John
dc.contributor.authorGinsberg, Henry N.
dc.date.accessioned2019-12-10T11:23:51Z
dc.date.available2019-12-10T11:23:51Z
dc.date.issued2015
dc.identifier.issn0195-668X
dc.identifier.urihttps://doi.org/10.1093/eurheartj/ehv043
dc.identifier.urihttp://hdl.handle.net/11655/15602
dc.description.abstractStatin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This European Atherosclerosis Society (EAS) Consensus Panel overviews current understanding of the pathophysiology of statin-associated myopathy, and provides guidance for diagnosis and management of SAMS. Statin-associated myopathy, with significant elevation of serum creatine kinase (CK), is a rare but serious side effect of statins, affecting 1 per 1000 to 1 per 10 000 people on standard statin doses. Statin-associated muscle symptoms cover a broader range of clinical presentations, usually with normal or minimally elevated CK levels, with a prevalence of 7-29% in registries and observational studies. Preclinical studies show that statins decrease mitochondrial function, attenuate energy production, and alter muscle protein degradation, thereby providing a potential link between statins and muscle symptoms; controlled mechanistic and genetic studies in humans are necessary to further understanding. The Panel proposes to identify SAMS by symptoms typical of statin myalgia (i.e. muscle pain or aching) and their temporal association with discontinuation and response to repetitive statin rechallenge. In people with SAMS, the Panel recommends the use of a maximally tolerated statin dose combined with non-statin lipid-lowering therapies to attain recommended low-density lipoprotein cholesterol targets. The Panel recommends a structured work-up to identify individuals with clinically relevant SAMS generally to at least three different statins, so that they can be offered therapeutic regimens to satisfactorily address their cardiovascular risk. Further research into the underlying pathophysiological mechanisms may offer future therapeutic potential.
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.isversionof10.1093/eurheartj/ehv043
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular System & Cardiology
dc.titleStatin-Associated Muscle Symptoms: Impact On Statin Therapy-European Atherosclerosis Society Consensus Panel Statement On Assessment, Aetiology And Management
dc.typeinfo:eu-repo/semantics/review
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalEuropean Heart Journal
dc.contributor.departmentKardiyoloji
dc.identifier.volume36
dc.identifier.issue17
dc.identifier.startpage1012
dc.identifier.endpage1022B
dc.description.indexWoS


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