Basit öğe kaydını göster

dc.contributor.authorFruchart, Jean-Charles
dc.contributor.authorDavignon, Jean
dc.contributor.authorHermans, Michel P
dc.contributor.authorAl-Rubeaan, Khalid
dc.contributor.authorAmarenco, Pierre
dc.contributor.authorAssmann, Gerd
dc.contributor.authorBarter, Philip
dc.contributor.authorBetteridge, John
dc.contributor.authorBruckert, Eric
dc.contributor.authorCuevas, Ada
dc.contributor.authorFarnier, Michel
dc.contributor.authorFerrannini, Ele
dc.contributor.authorFioretto, Paola
dc.contributor.authorGenest, Jacques
dc.contributor.authorGinsberg, Henry N
dc.contributor.authorGotto, Antonio M
dc.contributor.authorHu, Dayi
dc.contributor.authorKadowaki, Takashi
dc.contributor.authorKodama, Tatsuhiko
dc.contributor.authorKrempf, Michel
dc.contributor.authorMatsuzawa, Yuji
dc.contributor.authorNúñez-Cortés, Jesús Millán
dc.contributor.authorMonfil, Carlos Calvo
dc.contributor.authorOgawa, Hisao
dc.contributor.authorPlutzky, Jorge
dc.contributor.authorRader, Daniel J
dc.contributor.authorSadikot, Shaukat
dc.contributor.authorSantos, Raul D
dc.contributor.authorShlyakhto, Evgeny
dc.contributor.authorSritara, Piyamitr
dc.contributor.authorSy, Rody
dc.contributor.authorTall, Alan
dc.contributor.authorTan, Chee Eng
dc.contributor.authorTokgözoğlu, Lale
dc.contributor.authorToth, Peter P
dc.contributor.authorValensi, Paul
dc.contributor.authorWanner, Christoph
dc.contributor.authorZambon, Alberto
dc.contributor.authorZhu, Junren
dc.contributor.authorZimmet, Paul
dc.date.accessioned2019-12-10T11:23:48Z
dc.date.available2019-12-10T11:23:48Z
dc.date.issued2014
dc.identifier.issn1475-2840
dc.identifier.urihttps://doi.org/10.1186/1475-2840-13-26
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922777/
dc.identifier.urihttp://hdl.handle.net/11655/15596
dc.description.abstractCardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate the risk of vascular complications, patients remain at high risk of cardiovascular events. The Residual Risk Reduction Initiative (R3i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions. As part of its mission to improve awareness and clinical management of atherogenic dyslipidaemia, the R3i has identified three key priorities for action: i) to improve recognition of atherogenic dyslipidaemia in patients at high cardiometabolic risk with or without diabetes; ii) to improve implementation and adherence to guideline-based therapies; and iii) to improve therapeutic strategies for managing atherogenic dyslipidaemia. The R3i believes that monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk. Addition of a fibrate, niacin (North and South America), omega-3 fatty acids or ezetimibe are all options for combination with a statin to further reduce non-HDL cholesterol, although lacking in hard evidence for cardiovascular outcome benefits. Several emerging treatments may offer promise. These include the next generation peroxisome proliferator-activated receptorα agonists, cholesteryl ester transfer protein inhibitors and monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9. However, long-term outcomes and safety data are clearly needed. In conclusion, the R3i believes that ongoing trials with these novel treatments may help to define the optimal management of atherogenic dyslipidaemia to reduce the clinical and socioeconomic burden of residual cardiovascular risk.
dc.relation.isversionof10.1186/1475-2840-13-26
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleResidual Macrovascular Risk in 2013: What Have We Learned?
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCardiovascular Diabetology
dc.contributor.departmentKardiyoloji
dc.identifier.volume13
dc.identifier.startpage26
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster