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dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorOzmen, Fusun
dc.contributor.authorKocyigit, Duygu
dc.contributor.authorYersal, Nilgun
dc.contributor.authorBilgic, Elif
dc.contributor.authorKaya, Erkan
dc.contributor.authorKopru, Cagla Zubeyde
dc.contributor.authorSoyal, Tolga
dc.contributor.authorDoganci, Suat
dc.contributor.authorTokgozoglu, Lale
dc.contributor.authorKorkusuz, Petek
dc.date.accessioned2019-12-10T11:23:26Z
dc.date.available2019-12-10T11:23:26Z
dc.date.issued2017
dc.identifier.issn0914-5087
dc.identifier.urihttps://doi.org/10.1016/j.jjcc.2016.08.016
dc.identifier.urihttp://hdl.handle.net/11655/15567
dc.description.abstractBackground: Inflammatory activity originating from the epicardial adipose tissue (EAT) may have a role in coronary artery disease (CAD) pathogenesis. The relationship between macrophage infiltration, polarization in the EAT, and netrin-1 gene expression was investigated. Methods: Macrophage infiltration and polarization were examined by immunohistochemical methods and expression levels of netrin-1, Unc5b, and cytokines related with M1-macrophage subtype (IL-12 and IL-18) were determined by quantitative polymerase chain reaction in subcutaneous and epicardial adipose tissue obtained from patients undergoing coronary artery bypass grafting and non-coronary cardiac surgery. Results: CAD patients had higher CD68+ (p = 0.005) and CD11c+ (p < 0.001) macrophage count in EAT when compared to the controls. CD11c+/CD206+ macrophage ratio, which reflects dominancy of Ml macrophage phenotype, was significantly increased in EAT of CAD patients when compared to that of the controls (p = 0.008). CAD patients had significantly higher netrin-1, Unc5b, and IL-18 gene expression in the EAT when compared to the control group (p < 0.001, p < 0.001, and p = 0.006 respectively). Increased macrophage infiltration and polarization were associated with higher netrin-1, Unc5b, and IL-12 gene expression in EAT (p < 0.05). Conclusions: Findings suggest a link between enhanced netrin-1 expression in EAT and macrophage infiltration and polarization in patients with CAD. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.isversionof10.1016/j.jjcc.2016.08.016
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular System & Cardiology
dc.titleNetrin-1 Is Associated With Macrophage Infiltration And Polarization In Human Epicardial Adipose Tissue In Coronary Artery Disease
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalJournal Of Cardiology
dc.contributor.departmentKardiyoloji
dc.identifier.volume69
dc.identifier.issue6-May
dc.identifier.startpage851
dc.identifier.endpage858
dc.description.indexWoS
dc.description.indexScopus


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