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dc.contributor.authorAtalar, E
dc.contributor.authorHaznedaroglu, I
dc.contributor.authorAytemir, K
dc.contributor.authorAksoyek, S
dc.contributor.authorOvunc, K
dc.contributor.authorOto, A
dc.contributor.authorOzmen, F
dc.date.accessioned2019-12-10T11:21:48Z
dc.date.available2019-12-10T11:21:48Z
dc.date.issued2001
dc.identifier.issn0160-9289
dc.identifier.urihttps://doi.org/10.1002/clc.4960240211
dc.identifier.urihttp://hdl.handle.net/11655/15514
dc.description.abstractBackground: Adhesion molecules are known to be important in the regulation of endothelial cell and platelet functions. Increased platelets P-selectin expression is a marker of stent thrombosis after uncoated stent placement. Hypothesis: The aim of this study was to compare the effects of intracoronary placement of phosphorylcholine (PC)coated, versus heparin-coated, versus uncoated stents on platelets and endothelial activity. Methods: Thirty patients (age 55 +/- 10, 27 men) with significant proximal left anterior descending coronary artery stenoses were randomized to elective implantation of PC-coated, versus heparin-coated, versus uncoated stents. Following stent placement, intravenous heparin and aspirin plus ticlopidine were administered. Venous plasma soluble E-selectin. sP-selectin, and intercellular adhesion molecule-1 levels were measured before the procedure and 24 and 48 h thereafter as markers of platelet and endothelial cell activation. Patients were excluded if they had a disease known to influence platelet and endothelial cell function. Results: Plasma sP-selectin levels decreased significantly after implantation of PC- and heparin-coated stents (p = 0.04:), but remained unchanged in patients randomized to uncoated stents. Plasma sE-selectin levels increased significantly after uncoated stent placement (p = 0.01) and remained unchanged after coated stent implantation. Conclusion: In patients treated with combined antiplatelet therapy implantation of PC- and heparin-coated stents decreased platelet activity without activating endothelial cells, whereas placement of uncoated stents led to endothelial activation without changing platelet activity. These results suggest that PC-coated and heparin-coated stents may be advantageous in limiting thrombotic complications.
dc.language.isoen
dc.publisherClinical Cardiology Publ Co
dc.relation.isversionof10.1002/clc.4960240211
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular System & Cardiology
dc.titleEffects Of Stent Coating On Platelets And Endothelial Cells After Intracoronary Stent Implantation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalClinical Cardiology
dc.contributor.departmentKardiyoloji
dc.identifier.volume24
dc.identifier.issue2
dc.identifier.startpage159
dc.identifier.endpage164
dc.description.indexWoS


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