dc.contributor.author | Baltali, E | |
dc.contributor.author | Altundag, K | |
dc.contributor.author | Ozisik, Y | |
dc.contributor.author | Guler, N | |
dc.contributor.author | Tekuzman, G | |
dc.date.accessioned | 2019-12-10T11:21:17Z | |
dc.date.available | 2019-12-10T11:21:17Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0040-8727 | |
dc.identifier.uri | https://doi.org/10.1620/tjem.203.205 | |
dc.identifier.uri | http://hdl.handle.net/11655/15454 | |
dc.description.abstract | Single-agent paclitaxel has been shown to be effective as both first- and second-line treatment of metastatic breast cancer, and the efficacy and tolerability of weekly administration of paclitaxel has generated much interest. Fifty-two patients with pretreated metastatic breast cancer who were admitted to Hacettepe University between January 2001 and June 2002 were retrospectively analyzed in this study. Paclitaxel was administered weekly in a dose of 80 mg/m(2) over 1 hour. The median number of cycles delivered was 20 weeks (range, 8 to 24). The median delivered dose was 2400 mg (range, 960 to 3840 mg). At a median follow-up of 12.3 months (range, 6 to 17), all patients were assessable for response and toxicity. A complete response and partial response were observed in 7 (13.5%), and 19 (36.5%) patients, respectively. Overall response rate was 50%. Median duration of response was 10 months (range, 3 to 16). Therapy was generally well tolerated, and toxicities were manageable. Severe leukopenia was seen in two (4%) patients. Based on these results, we conclude that weekly paclitaxel is a well-tolerated and highly effective regimen in pre-treated metastatic breast cancer. (C) 2004 Tohoku University Medical Press. | |
dc.language.iso | en | |
dc.publisher | Tohoku Univ Medical Press | |
dc.relation.isversionof | 10.1620/tjem.203.205 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | General & Internal Medicine | |
dc.subject | Research & Experimental Medicine | |
dc.title | Weekly Paclitaxel In Pretreated Metastatic Breast Cancer: Retrospective Analysis Of 52 Patients | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Tohoku Journal Of Experimental Medicine | |
dc.contributor.department | İç hastalıkları | |
dc.identifier.volume | 203 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 205 | |
dc.identifier.endpage | 210 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |