Kemoterapi Alan Kanserli Çocuklarda Oral Mukozit Gelişimi ve Beslenme Durumu Ilişkisi

Abstract

This study was planned and conducted to evaluate the effect of chemotherapy on development of mucositis and its association with nutritional status in hospitalized children treated with chemotherapy. Sixty patients, who admitted to Hacettepe University Oncology Hospital Pediatric Oncology Department to take chemotherapy, aged 2-18, were included in this study. Patients were evaluated first day of admission and the last day of treatment, and among the patients 13 of them were re-evaluated when they re-admitted for mucositis. For each patient, anthropometric measurements were obtained and biochemical and hematological variables were evaluated for the first day, the last day and the day mucositis began. A daily (24 hours) food record was also completed for these three days. Appetite status was investigated via 5 point Likert scale and gastrointestinal symptoms were examined. In all patients and for the ones who developed mucositis, weight and BMI according to age decreased in the last day of therapy (p<0.001). The ones who had inappetency increased form 8.3% to 60.0% after chemotherapy. In the ones who developed mucositis, these rates increased form 7.7% to 84.6%. When compared to recommended dietary intake according to age, energy, protein, lipids (saturated, mono-unsaturated, poly-unsaturated and cholesterol), carbohydrates, fiber, vitamins A, B1, B2, B6, B12, C and folic acid, calcium, iron, zinc and copper decreased significantly at the last day of chemotherapy (p<0.001). For the ones who developed mucositis, especially energy, protein, lipids, carbohydrates and fiber intake was decreased as well as vitamins A, B6, B12 and folic acid and minerals (p<0.001). In conclusion, a loss of appetite and deterioration of nutritional status occur due to the adverse effects of chemotherapy which lead to weight loss. The results got heavier in case of mucositis.