Nonalkolik Yağlı Karaciğer Hastalığı Olan Bireylerde Fruktoz Tüketiminin Değerlendirilmesi

Abstract

This study was conducted to determine the level of fructose-rich foods consumption and evaluate a possible relationship between fructose intake and biochemical parameters in blood, anthropometric measurements in individuals who had non-alcoholic fatty liver disease. In this study, in varying degrees [grade1 (mild), grade 2 (moderate), grade 3 (severe)] steatosis detected 19 to 65 years old 45 individuals by abdominal ultrasonography examinations and 15 health individuals who were followed in Ankara Numune Education and Research Hospital Gastroenterology Clinic were included. Fructoserich food frequency questionnaire and 24-hour dietary record forms were administered to volunteers by the researcher. The individuals’ biochemical findings, anthropometric measurements and physical activity status were evaluated. The mean age of the healty subjects was 34 ± 9.2 years, while the mean age of the patients with NAFLD was 47 ± 11.2 years (p= 0.009). In all groups, anthropometric measurements (BMI, waist circumference, waist/hip ratio) increased with the increase in degree of hepatosteatosis and was statistically significant (p<0.001). Uric acid levels in grade 2 and grade 3 groups were higher than the reference limits (p<0.001). LDL levels in patients with NAFLD were higher than normal limits in all groups (p=0.130). ALT levels were higher in grade 2 and grade 3 groups, while AST levels were highest in grade 3 groups (p<0.001). Insulin resistance (HOMA-IR≥2.2) were observed in patients with NAFLD (p=0.033). Physical activity levels were not a significant difference among groups (p=0.099). The average daily consumption of carbonated soft drinks was least in grade 0 groups (8.7±5.7 ml), while it was the highest overconsumption in grade 3 groups (291±335.55 ml) (p=0.001). Fructose quantity which received food according to the degree of hepatosteatosis was the lowest in healty groups (grade 0), while in similar amounts and compared to other groups were higher in grade 2 and grade 3 groups (p<0.001). The energy level of sucrose in individuals with their daily diet were higher in grade 2 and grade 3 groups (p<0.001). Fructose consumption in individuals with relationships between variables regarding ** BMI ** waist circumference, * waist / hip ratio, * total cholesterol, ** uric acid, ** ALT, * AST, ** ALP, ** chocolate consumption, **fruit juice, *carbonated soft drinks was determined significant positive correlation (*p<0.05, ** p<0.01). There was significant positive correlations between the degree of hepatosteatosis and fructose consumption (r=0.979). As a result, the excessive consumption of fructose might be a cause of risk particularly non-alcoholic fatty liver disease, including obesity, type 2 diabetes, cardiovascular disease, metabolic syndrome, hypertension. Thus, daily dietary fructose intake should be supplied from natural resources.