dc.contributor.author | Kolgelier, Servet | |
dc.contributor.author | Demir, Nazlim Aktuğ | |
dc.contributor.author | Inkaya, Ahmet Cağkan | |
dc.contributor.author | Sumer, Sua | |
dc.contributor.author | Özcimen, Serap | |
dc.contributor.author | Demir, Lütfi Saltuk | |
dc.contributor.author | Pehlivan, Fatma Seher | |
dc.contributor.author | Arslan, Mahmure | |
dc.contributor.author | Arpaci, Abdullah | |
dc.date.accessioned | 2019-12-10T11:20:30Z | |
dc.date.available | 2019-12-10T11:20:30Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1735-143X | |
dc.identifier.uri | https://doi.org/10.5812/hepatmon.30655 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644632/ | |
dc.identifier.uri | http://hdl.handle.net/11655/15337 | |
dc.description.abstract | Background: Hepatologists have studied serologic markers of liver injury for decades. Annexins are a prominent group of such markers and annexin A2 (AnxA2) is one of the best characterized annexins. AnxA2 inhibits HBV polymerase among other functions. Its expression is up-regulated in regenerative hepatocytes. Objectives: To determine if serum AnxA2 level has a role in estimating liver damage in chronic HBV infection and investigate whether AnxA2 levels correlate with hepatic fibrosis. Patients and Methods: This study included 173 patients with chronic hepatitis B (CHB) and 51 healthy controls. Liver fibrosis was graded histologically on liver biopsy samples. Blood samples were taken from patients during biopsy and serum AnxA2 levels were measured with ELISA. Results: In a group of adult patients with CHB, AnxA2 values were far higher than those of the control group (P = 0.001). When we assessed AnxA2 levels based on fibrosis stages, serum AnxA2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; P = 0.001). Conclusions: AnxA2 is a useful biomarker for early stage fibrosis in patients with CHB. | |
dc.relation.isversionof | 10.5812/hepatmon.30655 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Serum Levels of Annexin A2 As a Candidate Biomarker For Hepatic Fibrosis in Patients with Chronic Hepatitis B | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Hepatitis Monthly | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 15 | |
dc.identifier.issue | 10 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |