dc.contributor.author | Ustun, N. | |
dc.contributor.author | Tok, F. | |
dc.contributor.author | Kalyoncu, U. | |
dc.contributor.author | Motor, S. | |
dc.contributor.author | Yuksel, R. | |
dc.contributor.author | Yagiz, A. E. | |
dc.contributor.author | Guler, H. | |
dc.contributor.author | Turhanoglu, A. D. | |
dc.date.accessioned | 2019-12-10T11:20:24Z | |
dc.date.available | 2019-12-10T11:20:24Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0303-464X | |
dc.identifier.uri | https://doi.org/ | |
dc.identifier.uri | http://hdl.handle.net/11655/15329 | |
dc.description.abstract | Objective: To determine the serum Dickkopf-related protein 1 (Dkk-1) and sclerostin levels, and their relationship to structural damage and disease activity in patients with ankylosing spondylitis (AS), as well as to compare the serum Dldc-1 and sclerostin levels in patients receiving and not receiving anti-TNF-alpha treatment. Materials and Methods: This cross-sectional study included 44 AS patients and 41 healthy age- and gender-matched controls. Demographic data, disease activity parameters, and Bath AnIcylosing Spondylitis Radiologic Index (BASRI) scores were recorded. Serum Dkk-1 and sclerostin levels were measured using commercially available ELISA. Results: Serum Dkk-1 levels were lower (P > 0.05) and sclerostin levels were significantly lower (P < 0.05) in the AS patients than in the controls. Dkk-1 and sclerostin levels were similar in the patients that did and didn't receive anti-TNF-alpha treatment, and in the patients with active and inactive disease (P > 0.05). There wasn't a correlation between serum Dkk-1 or sclerostin levels, and disease activity indices (P > 0.05). BASRI scores did not correlate with serum Dkk-1 or sclerostin levels (P > 0.05). Discussion: Sclerostin expression is impaired in AS, but this is not the case for Dkk-1. The lack of an association between Dkk-1 or sclerostin levels, and anti-TNF-alpha treatment, disease activity indices, and radiological damage might indicate that neither the Dkk-1 nor sclerostin level induce inflammation and radiological damage in AS patients. Pathologic bone formation in AS might be due to molecular dysfunction of sclerostin and Dkk-1 at the cellular level. | |
dc.language.iso | en | |
dc.publisher | Publisaude-Edicoes Medicas Lda | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Rheumatology | |
dc.title | Sclerostin And Dkk-1 In Patients With Ankylosing Spondylitis | |
dc.type | info:eu-repo/semantics/article | |
dc.relation.journal | Acta Reumatologica Portuguesa | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 146 | |
dc.identifier.endpage | 151 | |
dc.description.index | WoS | |