dc.contributor.author | Çalık Başaran, Nursel | |
dc.contributor.author | Karaağaoğlu, Ergun | |
dc.contributor.author | Hasçelik, Gülşen | |
dc.contributor.author | Durusu Tanrıöver, Mine | |
dc.contributor.author | Akova, Murat | |
dc.date.accessioned | 2019-12-10T11:20:16Z | |
dc.date.available | 2019-12-10T11:20:16Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1300-7777 | |
dc.identifier.uri | https://doi.org/10.4274/tjh.2015.0216 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204186/ | |
dc.identifier.uri | http://hdl.handle.net/11655/15293 | |
dc.description.abstract | Objective: We aimed to determine the frequency, type, and etiology of infections and the risk factors for infections and mortality in hospitalized cancer patients. Materials and Methods: We prospectively enrolled adult cancer patients hospitalized in the internal medicine wards of a tertiary care academic center between January and August 2004. Patients were followed during their hospitalization periods for neutropenia, infections, culture results, and mortality. Results: We followed 473 cancer patients with 818 hospitalization episodes and 384 infection episodes in total. Seventy-nine percent of the infections were nosocomial, and febrile neutropenia (FN) was observed in 196 (51%) of the infection episodes. Bacteremia was found in 29% of FN episodes and in 8% of nonneutropenic patients. Gram-positive bacteria were the leading cause of bacteremia in both neutropenic and nonneutropenic cases (70% and 58%, respectively). Presence of an indwelling central catheter increased bacteremia risk by 3-fold. The overall mortality rate was 17%, whereas 34% of the patients with bloodstream infections died. Presence of bacteremia and advanced disease stage increased overall mortality by 6.1-fold and 3.7-fold, respectively. Conclusion: Nearly half of the cancer patients developed an infection during their hospital stays, with gram-positive bacteria being the predominant etiologic microorganisms. This demonstrates the changing trends in infections considering that, until 2004, gram-negative bacteria were the most predominant microorganisms among cancer patients in our institute. | |
dc.relation.isversionof | 10.4274/tjh.2015.0216 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Prospective Evaluation of Infection Episodes in Cancer Patients in a Tertiary Care Academic Center: Microbiological Features and Risk Factors for Mortality | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal of Hematology | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 33 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 311 | |
dc.identifier.endpage | 319 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |
dc.description.index | Scopus | |