dc.contributor.author | Hennes, Eva-Maria | |
dc.contributor.author | Baumann, Matthias | |
dc.contributor.author | Schanda, Kathrin | |
dc.contributor.author | Anlar, Banu | |
dc.contributor.author | Bajer-Kornek, Barbara | |
dc.contributor.author | Blaschek, Astrid | |
dc.contributor.author | Brantner-Inthaler, Sigrid | |
dc.contributor.author | Diepold, Katharina | |
dc.contributor.author | Eisenkolbl, Astrid | |
dc.contributor.author | Gotwald, Thaddaeus | |
dc.contributor.author | Kuchukhidze, Georgi | |
dc.contributor.author | Gruber-Sedlmayr, Ursula | |
dc.contributor.author | Haeusler, Martin | |
dc.contributor.author | Hoeftberger, Romana | |
dc.contributor.author | Karenfort, Michael | |
dc.contributor.author | Klein, Andrea | |
dc.contributor.author | Koch, Johannes | |
dc.contributor.author | Kraus, Verena | |
dc.contributor.author | Lechner, Christian | |
dc.contributor.author | Leiz, Steffen | |
dc.contributor.author | Leypoldt, Frank | |
dc.contributor.author | Mader, Simone | |
dc.contributor.author | Marquard, Klaus | |
dc.contributor.author | Poggenburg, Imke | |
dc.contributor.author | Pohl, Daniela | |
dc.contributor.author | Pritsch, Martin | |
dc.contributor.author | Raucherzauner, Markus | |
dc.contributor.author | Schimmel, Mareike | |
dc.contributor.author | Thiels, Charlotte | |
dc.contributor.author | Tibussek, Daniel | |
dc.contributor.author | Vieker, Silvia | |
dc.contributor.author | Zeches, Carolin | |
dc.contributor.author | Berger, Thomas | |
dc.contributor.author | Reindl, Markus | |
dc.contributor.author | Rostasy, Kevin | |
dc.date.accessioned | 2019-12-10T11:20:13Z | |
dc.date.available | 2019-12-10T11:20:13Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0028-3878 | |
dc.identifier.uri | https://doi.org/10.1212/WNL.0000000000004312 | |
dc.identifier.uri | http://hdl.handle.net/11655/15288 | |
dc.description.abstract | Objective: To assess the prognostic value of MOG antibodies (abs) in the differential diagnosis of acquired demyelinating syndromes (ADS). Methods: Clinical course, MRI, MOG-abs, AQP4-abs, and CSF cells and oligoclonal bands (OCB) in children with ADS and 24 months of follow-up were reviewed in this observational prospective multicenter hospital-based study. Results: Two hundred ten children with ADS were included and diagnosed with acute disseminated encephalomyelitis (ADEM) (n = 60), neuromyelitis optica spectrum disorder (NMOSD) (n = 12), clinically isolated syndrome (CIS) (n = 101), and multiple sclerosis (MS) (n = 37) after the first episode. MOG-abs were predominantly found in ADEM (57%) and less frequently in NMOSD (25%), CIS (25%), or MS (8%). Increased MOG-ab titers were associated with younger age (p = 0.0001), diagnosis of ADEM (p = 0.005), increased CSF cell counts (p = 0.011), and negative OCB (p = 0.012). At 24-month follow-up, 96 children had no further relapses. Thirtyfive children developed recurrent non-MS episodes (63% MOG-, 17% AQP4-abs at onset). Seventy-nine children developed MS (4% MOG-abs at onset). Recurrent non-MS episodes were associated with high MOG-ab titers (p = 0.0003) and older age at onset (p = 0.024). MS was predicted by MS-like MRI (p < 0.0001) and OCB (p = 0.007). An MOG-ab cutoff titer >= 1:1,280 predicted a non-MS course with a sensitivity of 47% and a specificity of 100% and a recurrent non-MS course with a sensitivity of 46% and a specificity of 86%. Conclusions: Our results show that the presence of MOG-abs strongly depends on the age at disease onset and that high MOG-ab titers were associated with a recurrent non-MS disease course. | |
dc.language.iso | en | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.relation.isversionof | 10.1212/WNL.0000000000004312 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Neurosciences & Neurology | |
dc.title | Prognostic Relevance of Mog Antibodies in Children With an Acquired Demyelinating Syndrome | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Neurology | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 89 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 900 | |
dc.identifier.endpage | 908 | |
dc.description.index | WoS | |