In Vitro Activity Of Tigecycline Against Brucella Spp.

Abstract

Objectives: There are no published data regarding efficacy of tigecycline in brucellosis and in vitro data are scarce. We compared the in vitro activity of tigecycline to that of trimethoprim-sulfamethoxazole, rifampicin, tetracycline, streptomycin and ciprofloxacin against Brucella spp. Study Design: In vitro activities of tigecycline, trimethoprim-sulfamethoxazole, rifampicin, tetracycline, streptomycin and ciprofloxacin were evaluated against 96 strains of Brucella spp. Minimal inhibitory concentrations (MIC) were determined by the E-test method. Results: Tigecycline had low MIC(50) and MIC(90) values against all Brucella isolates; the highest MIC observed was 0.19 mu g/mL. Conclusion: Tigecycline had low MICs against Brucella spp. including tetracycline-resistant isolates and its use in therapy should be confirmed by clinical studies.