dc.contributor.author | Boyraz, Gokhan | |
dc.contributor.author | Basaran, Derman | |
dc.contributor.author | Salman, Mehmet Coskun | |
dc.contributor.author | Ibrahimov, Akbar | |
dc.contributor.author | Onder, Sevgen | |
dc.contributor.author | Akman, Orkun | |
dc.contributor.author | Ozgul, Nejat | |
dc.contributor.author | Yuce, Kunter | |
dc.date.accessioned | 2019-12-10T11:13:45Z | |
dc.date.available | 2019-12-10T11:13:45Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0970-9371 | |
dc.identifier.uri | https://doi.org/10.4103/JOC.JOC_209_16 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655657/ | |
dc.identifier.uri | http://hdl.handle.net/11655/15100 | |
dc.description.abstract | Context: Atypical glandular cells (AGCs) result in the Papanicolaou (Pap) smear may be associated with significant genital and nongenital neoplastic processes. Aims: To evaluate the underlying histopathology in women who had AGCs on Pap smears. Settings and Design: Retrospective cross-sectional study. Patients and Methods: Clinicopathological data of patients who had AGC on Pap smears and underwent histological workup between January 2004 and December 2014 were retrieved from the computerized database of a tertiary care center. Patients with a prior history of cervical intraepithelial neoplasia or gynecological cancer were excluded. Statistical Analysis Used: Chi-square test or Fisher's exact tests were used as appropriate. Results: Cytological examination of the uterine cervix was carried out in 117,560 patients. We identified 107 patients (0.09%) with AGC and 80 of those with histological follow-up were included in the study. The median age at diagnosis was 47 years (range, 18–79), and 32 women (40%) were postmenopausal, while 56 (70%) had gynecological symptoms. Significant preinvasive or invasive lesions on pathological examination were detected in 27 (33.8%) patients, including 12 endometrial adenocarcinomas (15%), 8 cervical carcinomas (10%), 3 cervical intraepithelial neoplasia II/III (3.75%), 2 ovarian adenocarcinomas (2.5%), and 2 metastatic tumors (2.5%). Univariate analysis showed that postmenopausal status (P < 0.001), age >50 years old (P < 0.001), having symptoms at the time of admission (P = 0.041), and AGC “favor neoplasia” smear results (P = 0.041) were the clinical factors associated with significant pathological outcome. Conclusions: Patients with AGC on Pap smears should be evaluated vigilantly with histological workup, especially if they are postmenopausal or symptomatic. | |
dc.relation.isversionof | 10.4103/JOC.JOC_209_16 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Histological Follow-Up In Patients With Atypical Glandular Cells On Pap Smears | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal of Cytology | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 34 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 203 | |
dc.identifier.endpage | 207 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |
dc.description.index | Scopus | |