dc.contributor.author | Usalan, Celalettin | |
dc.contributor.author | Erdem, Yunus | |
dc.contributor.author | Çağlar, Meltem | |
dc.contributor.author | Altun, Bülent | |
dc.contributor.author | Arıcı, Mustafa | |
dc.contributor.author | Bakkaloğlu, M | |
dc.contributor.author | Yasavul, U | |
dc.contributor.author | Turgan, C | |
dc.contributor.author | Çağlar, S | |
dc.date.accessioned | 2019-12-10T11:11:57Z | |
dc.date.available | 2019-12-10T11:11:57Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 0931-0509 | |
dc.identifier.uri | https://doi.org/10.1093/ndt/13.11.2884 | |
dc.identifier.uri | http://hdl.handle.net/11655/15000 | |
dc.description.abstract | Background. Exaggerated erythropoietin (EPO) response to phlebotomy regardless of the baseline EPO levels have been shown in patients with post-transplant erythrocytosis (PTE) and administration of angiotensin-converting enzyme inhibitors (ACE-1) seems to be effective in controlling PTE. However, the mechanism of this ACE-1 induced reduction in haematocrit (Hct) is not well known. Although some authors have suggested that ACE-1 may reduce EPO secretion, this is still controversial. The aim of the present study was to assess the effect of a single dose ACE-1 on exaggerated EPO response to phlebotomy. Methods. In this study. we compared serum EPO and renin (PRA levels of 10 PTE patients, 10 non-PTE patients and 10 healthy blood donors before and after phlebotomy. The effects of a single dose of ACE-1 (enalapril, 5 mg p.o.) in PTE patients were also evaluated in the second phlebotomy. Results. While the mean basal serum EPO level was significantly higher in the PTE group than the other two groups (P < 0.01), the mean basal PRA levels did not differ significantly between these groups. Serum EPO and PRA levels increased significantly after the phlebotomy (P < 0.001) and exaggerated EPO response to phlebotomy was suppressed by single dose enalapril (P < 0.001) in the PTE patients. Conclusion. The present study has shown that the renin-angiotensin system plays an important role in EPO formation and the Hct lowering effect of the ACE-1 is through reduction of EPO in PTE patients. | |
dc.language.iso | en | |
dc.publisher | Oxford Univ Press | |
dc.relation.isversionof | 10.1093/ndt/13.11.2884 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Transplantation | |
dc.subject | Urology & Nephrology | |
dc.title | Effect of Enalapril on Exaggerated Erythropoietin Response to Phlebotomy in Erythrocytosic Renal Transplant Patients | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Nephrology Dialysis Transplantation | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 11 | |
dc.identifier.startpage | 2884 | |
dc.identifier.endpage | 2889 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |