dc.contributor.author | Şentürk, Berna | |
dc.contributor.author | Demircan, Burak M. | |
dc.contributor.author | Özkan, Alper D. | |
dc.contributor.author | Tohumeken, Sehmus | |
dc.contributor.author | Delibasi, Tuncay | |
dc.contributor.author | Güler, Mustafa O. | |
dc.contributor.author | Tekinay, Ayse B. | |
dc.date.accessioned | 2019-12-10T11:11:36Z | |
dc.date.available | 2019-12-10T11:11:36Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2047-4830 | |
dc.identifier.uri | https://doi.org/10.1039/c7bm00251c | |
dc.identifier.uri | http://hdl.handle.net/11655/14975 | |
dc.description.abstract | There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response. | |
dc.language.iso | en | |
dc.publisher | Royal Soc Chemistry | |
dc.relation.isversionof | 10.1039/c7bm00251c | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Materials Science | |
dc.title | Diabetic Wound Regeneration Using Heparin-Mimetic Peptide Amphiphile Gel In Db/Db Mice | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Biomaterials Science | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 5 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 1293 | |
dc.identifier.endpage | 1303 | |
dc.description.index | WoS | |