dc.contributor.author | Uz, Burak | |
dc.contributor.author | Eliaçık, Eylem | |
dc.contributor.author | Işık, Ayse | |
dc.contributor.author | Aksu, Salih | |
dc.contributor.author | Büyükaşık, Yahya | |
dc.contributor.author | Haznedaroğlu, İbrahim C. | |
dc.contributor.author | Göker, Hakan | |
dc.contributor.author | Sayınalp, Nilgün | |
dc.contributor.author | Özcebe, Osman İ. | |
dc.date.accessioned | 2019-12-10T11:11:05Z | |
dc.date.available | 2019-12-10T11:11:05Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1300-7777 | |
dc.identifier.uri | https://doi.org/10.4274/Tjh.2012.0180 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874972/ | |
dc.identifier.uri | http://hdl.handle.net/11655/14941 | |
dc.description.abstract | Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m2/day) and daily all-trans retinoic acid (ATRA; 45 mg/m2/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 µg RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m2/day), ATRA (45 mg/m2/day for 15 days), and cytarabine (1 g/m2/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis. , Conflict of interest:None declared. | |
dc.relation.isversionof | 10.4274/Tjh.2012.0180 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Co-Expression Of T(15;17) And T(8;21) In A Case Of Acute Promyelocytic Leukemia: Review Of The Literature | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal of Hematology | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 400 | |
dc.identifier.endpage | 404 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |