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dc.contributor.authorGunduzoz, Meide
dc.contributor.authorIritas, Servet Birgin
dc.contributor.authorTutkun, Lutfiye
dc.contributor.authorBuyuksekerci, Murat
dc.contributor.authorCetintepe, Sultan Pinar
dc.contributor.authorBal, Ceylan
dc.contributor.authorAlisik, Murat
dc.contributor.authorErdogan, Serpil
dc.contributor.authorYilmaz, Hinc
dc.contributor.authorErel, Ozcan
dc.date.accessioned2019-12-10T11:10:04Z
dc.date.available2019-12-10T11:10:04Z
dc.date.issued2018
dc.identifier.issn1210-7778
dc.identifier.urihttps://doi.org/10.21101/cejph.a4972
dc.identifier.urihttp://hdl.handle.net/11655/14805
dc.description.abstractObjectives: The aim of this study was to investigate the associations between urinary arsenic, oxidative stress, assessed by thiol/disulphide homeostasis, and lung diseases in firefighters. Methods: The study conducted among the municipality-based male firefighters (n = 100) who were admitted to occupational diseases clinic for periodic medical examination. The control group consisted of non-exposed male office workers (n = 50). Urinary arsenic levels, thiol/disulphide homeostasis parameters of participants were determined. Also, lung diseases were assessed by chest X-ray and pulmonary function tests. Results: The mean age and work year did not differ in the study and control group. The median urinary arsenic concentration of firefighters was significantly higher than in the control group: 15.65 (2.5-246) mu g/L and 3 (0.10-6) mu g/L, respectively (p < 0.001). The parameters of pulmonary function tests (PFT) FVC (%), FEV1 (%), FEV1/FVC ratio and FEF 25-75 (%) were all significantly lower in firefighters compared to controls. A significant increase in mean serum disulphide concentration (17.10 +/- 8.31 mu mol/L vs. 7.48 +/- 5.91) (Fig. 1) and disulphide/native thiol % ratio: 3.63 (0.53-11.43) vs. 1.51 (0.03-7.65) (p < 0.001) were found between exposed group and controls. The Spearman's correlation analysis revealed a positive correlation between urinary arsenic and disulphide (r = 0.422, p < 0.001), disulphide/native thiol % ratio (r = 0.409, p < 0.001). Nevertheless, urinary arsenic correlated negatively with all PFT parameters including FVC (%), FEV1 (%), FEV1/FVC and FEF 25-75 (%) (p < 0.001). Conclusion: We showed the arsenic-induced oxidative stress in firefighters with impairments of several lung functions determined by thiol/disulphide homeostasis using a novel method.
dc.language.isoen
dc.publisherNatl Inst Public Health
dc.relation.isversionof10.21101/cejph.a4972
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPublic, Environmental & Occupational Health
dc.titleA New Potential Biomarker in Early Diagnosis of Firefighter Lung Function Impairment: Dynamic Thiol/Disulphide Homeostasis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCentral European Journal Of Public Health
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume26
dc.identifier.issue3
dc.identifier.startpage190
dc.identifier.endpage194
dc.description.indexWoS
dc.description.indexScopus


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