dc.contributor.author | Speer, Scott D. | |
dc.contributor.author | Li, Zhi | |
dc.contributor.author | Buta, Sofija | |
dc.contributor.author | Payelle-Brogard, Béatrice | |
dc.contributor.author | Qian, Li | |
dc.contributor.author | Vigant, Frederic | |
dc.contributor.author | Rubino, Erminia | |
dc.contributor.author | Gardner, Thomas J. | |
dc.contributor.author | Wedeking, Tim | |
dc.contributor.author | Hermann, Mark | |
dc.contributor.author | Duehr, James | |
dc.contributor.author | Sanal, Ozden | |
dc.contributor.author | Tezcan, Ilhan | |
dc.contributor.author | Mansouri, Nahal | |
dc.contributor.author | Tabarsi, Payam | |
dc.contributor.author | Mansouri, Davood | |
dc.contributor.author | Francois-Newton, Véronique | |
dc.contributor.author | Daussy, Coralie F. | |
dc.contributor.author | Rodriguez, Marisela R. | |
dc.contributor.author | Lenschow, Deborah J. | |
dc.contributor.author | Freiberg, Alexander N. | |
dc.contributor.author | Tortorella, Domenico | |
dc.contributor.author | Piehler, Jacob | |
dc.contributor.author | Lee, Benhur | |
dc.contributor.author | García-Sastre, Adolfo | |
dc.contributor.author | Pellegrini, Sandra | |
dc.contributor.author | Bogunovic, Dusan | |
dc.date.accessioned | 2019-12-10T10:39:20Z | |
dc.date.available | 2019-12-10T10:39:20Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://doi.org/10.1038/ncomms11496 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873964/ | |
dc.identifier.uri | http://hdl.handle.net/11655/14115 | |
dc.description.abstract | ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have demonstrated a role for Isg15 in antiviral immunity. By contrast, human ISG15 was shown to have critical immune functions, but not in antiviral immunity. Namely, free extracellular ISG15 is crucial in IFN-γ-dependent antimycobacterial immunity, while free intracellular ISG15 is crucial for USP18-mediated downregulation of IFN-α/β signalling. Here we describe ISG15-deficient patients who display no enhanced susceptibility to viruses in vivo, in stark contrast to Isg15-deficient mice. Furthermore, fibroblasts derived from ISG15-deficient patients display enhanced antiviral protection, and expression of ISG15 attenuates viral resistance to WT control levels. The species-specific gain-of-function in antiviral immunity observed in ISG15 deficiency is explained by the requirement of ISG15 to sustain USP18 levels in humans, a mechanism not operating in mice., ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection. | |
dc.relation.isversionof | 10.1038/ncomms11496 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Isg15 Deficiency and Increased Viral Resistance in Humans but Not Mice | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Nature Communications | |
dc.contributor.department | Çocuk Sağlığı ve Hastalıkları | |
dc.identifier.volume | 7 | |
dc.description.index | PubMed | |
dc.description.index | WoS | |
dc.description.index | Scopus | |