dc.contributor.author | MacLennan, C | |
dc.contributor.author | Fieschi, C | |
dc.contributor.author | Lammas, DA | |
dc.contributor.author | Picard, C | |
dc.contributor.author | Dorman, SE | |
dc.contributor.author | Sanal, O | |
dc.contributor.author | MacLennan, JM | |
dc.contributor.author | Holland, SM | |
dc.contributor.author | Ottenhoff, THM | |
dc.contributor.author | Casanova, JL | |
dc.contributor.author | Kumararatne, DS | |
dc.date.accessioned | 2019-12-10T10:39:05Z | |
dc.date.available | 2019-12-10T10:39:05Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0022-1899 | |
dc.identifier.uri | https://doi.org/10.1086/425021 | |
dc.identifier.uri | http://hdl.handle.net/11655/14099 | |
dc.description.abstract | Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)-gamma axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN-gamma-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-gamma-independent pathways. Investigation of the IL-12/IL-23-IFN-gamma axis should be considered in patients with invasive salmonella disease. | |
dc.language.iso | en | |
dc.publisher | Univ Chicago Press | |
dc.relation.isversionof | 10.1086/425021 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Immunology | |
dc.subject | Infectious Diseases | |
dc.subject | Microbiology | |
dc.title | Interleukin (Il)-12 And Il-23 Are Key Cytokines For Immunity Against Salmonella In Humans | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/conferenceObject | |
dc.relation.journal | Journal Of Infectious Diseases | |
dc.contributor.department | Çocuk Sağlığı ve Hastalıkları | |
dc.identifier.volume | 190 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1755 | |
dc.identifier.endpage | 1757 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |