dc.contributor.author | Kandemir, Nurgün | |
dc.contributor.author | Demirbilek, Hüseyin | |
dc.contributor.author | Özön, Zeynep Alev | |
dc.contributor.author | Gönç, Nazlı | |
dc.contributor.author | Alikaşifoğlu, Ayfer | |
dc.date.accessioned | 2019-12-10T10:38:13Z | |
dc.date.available | 2019-12-10T10:38:13Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1308-5727 | |
dc.identifier.uri | https://doi.org/10.4274/jcrpe.v3i1.03 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065310/ | |
dc.identifier.uri | http://hdl.handle.net/11655/14043 | |
dc.description.abstract | Objective: Gonadotropin stimulation test is the gold standard to document precocious puberty. However, the test is costly, time-consuming and uncomfortable. The aim of this study was to simplify the intravenous gonadotropin-releasing hormone (GnRH) stimulation test in the diagnosis of precocious puberty and in the assessment of pubertal suppression. , Methods: Data pertaining to 584 GnRH stimulation tests (314 testsfor diagnosis and 270 for assessment of pubertal suppression) were analyzed. , Results: Forty-minute post-injection samples had the greatest frequency of “peaking luteinizing hormone (LH)” (p<0.001) in the diagnostic tests when the cut-off value was taken as 5 IU/L for LH, 40th minute sample was found to have 98% sensitivity and 100% specificity in the diagnosis of precocious puberty, while the sensitivity and specificity of the 20th minute sample was 100% in the assessment of pubertal suppression. , Conclusion: LH level at the 40th minute post-injection in the diagnosis of central precocious puberty and at the 20th minute post-injection in the assessment of pubertal suppression is highly sensitive and specific. A single sample at these time points can be used in the diagnosis of early puberty and in the assessment of pubertal suppression. , Conflict of interest:None declared. | |
dc.relation.isversionof | 10.4274/jcrpe.v3i1.03 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Gnrh Stimulation Test In Precocious Puberty: Single Sample Is Adequate For Diagnosis And Dose Adjustment | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal of Clinical Research in Pediatric Endocrinology | |
dc.contributor.department | Çocuk Sağlığı ve Hastalıkları | |
dc.identifier.volume | 3 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 17-Dec | |
dc.description.index | PubMed | |
dc.description.index | Scopus | |