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dc.contributor.authorUz, Elif
dc.contributor.authorMustafa, Chigdem
dc.contributor.authorTopaloglu, Rezan
dc.contributor.authorBilginer, Yelda
dc.contributor.authorDursun, Ali
dc.contributor.authorKasapcopur, Ozgur
dc.contributor.authorOzen, Seza
dc.contributor.authorBakkaloglu, Aysin
dc.contributor.authorOzcelik, Tayfun
dc.date.accessioned2019-12-10T10:34:14Z
dc.date.available2019-12-10T10:34:14Z
dc.date.issued2009
dc.identifier.issn0004-3591
dc.identifier.urihttps://doi.org/10.1002/art.24956
dc.identifier.urihttp://hdl.handle.net/11655/13764
dc.description.abstractObjective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA. Methods. A polymorphic repeat in the androgen receptor gene was genotyped to determine XCI status in 81 female patients with JIA (21 with polyarticular disease and 60 with oligoarticular disease) and 211 healthy female controls. DNA obtained from venous blood samples was used for this analysis. Results. Informative data were obtained on 62 JIA patients and 155 controls. Skewed XCI was observed in 14 patients (22.6%) and 11 controls (7.1%) (P = 0.0036), and extreme skewing was apparent in 8 patients (12.9%) and 2 controls (1.3%) (P = 0.0008). Conclusion. Our findings in the present study indicate that skewed XCI may be a risk factor for the occurrence of autoimmune disorders, including JIA.
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.isversionof10.1002/art.24956
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRheumatology
dc.titleIncreased Frequency Of Extremely Skewed X Chromosome Inactivation In Juvenile Idiopathic Arthritis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalArthritis And Rheumatism
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları
dc.identifier.volume60
dc.identifier.issue11
dc.identifier.startpage3410
dc.identifier.endpage3412
dc.description.indexWoS


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