Browsing Sağlık Bilimleri Enstitüsü by Title
Now showing items 55-74 of 99
-
Kompleks Hastalıklarla İlişkili Genetik Varyasyonun Zaman-Serisi Genom Dizileme Verilerinde Popülasyon Genetiği Yaklaşımları ile İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-06-19)Genetic diseases are the products of evolutionary process. The demographic history of anatomically modern humans over the last 200.000 years has shaped the genetic structure associated with common diseases. It is possible ... -
Kord Kanındaki Kemokin Düzeylerinin Prematüre Bebeklerdeki Oksidatif Stres Kaynaklı Morbiditeler ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2023)Oxidative stress occurs when free radicals increase and exceed the levels of antioxidant mechanisms that can neutralize them. It causes tissue damage by causing protein, lipid and polysaccharide oxidation, DNA fragmentation, ... -
Kumaş Fazı Emici Ekstraksiyonu ile İlaç Etkin Maddelerinin Farmasötik Preparat ve Biyolojik Materyalden Analizi için Analitik Yöntem Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2024-01-08)Fabric phase absorbent extraction (FPSE) is a sample preparation technique that has come to the fore in recent years. Microextraction devices prepared by coating a fabric surface with different sorbents enable the analysis ... -
Kurşun Maruziyetinin ve Şelasyon Tedavisinin Toksisiteyi Etkileyen Bazı Parametreler Üzerine Etkisinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023-01)Lead (Pb) is a heavy metal with substantial toxic properties which is broadly used across industries in Turkey and around the world. Sodium calcium EDTA is an important chelation agent used in the treatment. In this ... -
Metabolom ve Transkriptom Profillemesi ile İnsan Kemik İliğinde Hematopoetik Niş Karakterizasyonu
(Çocuk Sağlığı Enstitüsü, 2015)In model organisms and animal experiments, it has been shown that hematopoietic stem cells (HSC) in bone marrow have special organizations and they provide this organization through special microenvironment called niche. ... -
Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells
(Sağlık Bilimleri Enstitüsü, 2021-08-09)Methionine is an essential amino acid critical in protein synthesis and methylation reactions. In this thesis, it is aimed to determine the effect of methionine on different human stem cell groups. Mesenchymal stem cells ... -
Metronidazol, Mikonazol ve Lidokain’in Farmasötik Preparattan Aynı Anda Analizi İçin Yüksek Performanslı Sıvı Kromatografisi (Hplc) Yönteminin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)Talay, Ç. Development of High Performance Liquid Chromatography (HPLC) Method For Simultaneous Analysis Of Metronidazole, Miconazole and Lidocaine Mixture from Pharmaceutical Preparation, Hacettepe University Graduate ... -
Mezenkimal Kök Hücre Üretiminde İn Vitro Temelli Metabolomik ve Analizler
(Sağlık Bilimleri Enstitüsü, 2020-02-12)Karaağaç Akyol, T. Metabolomic And Analyzes In In-Vitro Based On The Production Of Mesenchimal Stem Cells, Hacettepe University Graduate School of Health Sciences Stem Cells Program Doctor of Philosophy Thesis, Ankara, ... -
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ... -
Mezenkimal Kök Hücrelerin Diamond Blackfan Anemisi Hastalığındaki Rolünün Aydınlatılması
(Sağlık Bilimleri Enstitüsü, 2018-07)In this thesis, the molecular etiology of Diamond Blackfan Anemia is tried to be enlightened. For this purpose, bone marrow mesenchymal and hematopoietic stem cells from the patients were comparatively analyzed with healthy ... -
Mezenkimal Kök Hücrelerin In Vıtro Koşullarda Testis Mikroçevresi ve Spermatogonyal Kök Hücre Havuzunun Korunmasına Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)Önen, S. Researching The Effect of Mesenchymal Stem Cells on the Testicular Microenvironment and the Spermatogonial Stem Cell Pool Under in vitro Conditions. Hacettepe University Graduate School of Health Sciences, Master ... -
Migren Tedavisinde Kullanılmak Üzere Geliştirilen Hibrit Nanopartiküllerin İn Vitro ve İn Vivo Etkinliklerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Kaya MZ. Evaluation of In Vitro and In Vivo Activities of Hybrid Nanoparticles Developed for the Treatment of Migraine, PhD Thesis, Pharmaceutical Technology Program, Graduate School of Health Sciences, Hacettepe University, ... -
Mikrodizin kaynaklı genotip bilgisi kullanılarak kopya sayısı değişikliklerinde mozaiklik oranının saptanması
(Sağlık Bilimleri Enstitüsü, 2023)Acun, H. M., Determination of Mosaicism Ratio in Copy Number Variations Using Microarray Based Genotype Information, Hacettepe University Graduate School of Health Sciences Department of Bioinformatics Master’s Thesis, ... -
Mikrorna-21 Baskılanmış Meme Kanseri Kök Hücrelerinin İnsan Kemik İliğinden İzole Edilen Telositler ve Telosit Kaynaklı Mitokondriler ile Ko-Kültürü
(Sağlık Bilimleri Enstitüsü, 2023)The aim of this thesis study was to investigate the contribution of telocytes and telocyte-derived mitochondria, which have also been identified in breast tumours, to the tumour development of breast cancer stem cells via ... -
Myastenia Gravis’li Bireylerde Kognitif İşlevin Basit ve Kompleks Reaksiyon Zamanı Yöntemi ile Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Myasthenia Gravis (MG) is an autoimmune disease caused by antibodies against mainly postsynaptic proteins that play an important role in the function of the neuromuscular junction. Function disruption of the junction leads ... -
Myeloid Kanserlerde Kemik İliği Mikroçevresinin Metabolik Profilinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2024-07-01)ŞAHİN A. B., Investigation of the metabolic profile of the bone marrow microenvironment in myeloid cancers, Hacettepe University Graduate School of Health Sciences, Stem Cell Program Master Thesis, Ankara, 2024. Metabolic ... -
Non-Segmental Vitiligo ile HLA Genotipi Ve Oksidatif Stres Arasındaki İlişki
(Sağlık Bilimleri Enstitüsü, 2019)Vitiligo is an autoimmune skin diseases characterized by acquired loss of functional melanocytes. Although the pathogenesis of vitiligo remains poorly understood, oxidative stress and autoimmune disregulations are considered ... -
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ... -
Oksidatif Stres Altında Mezenkimal Kök Hücrelerde Src-YAP Aktivitesi ve Apoptoz ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2024)One of the reasons for the post-transplantation loss of mesenchymal stem cells (MSCs), which are used in the treatment of many diseases with their immunomodulatory and regenerative properties, is oxidative stress-induced ... -
Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives Using Current Molecular Techniques and Technologies
(Sağlık Bilimleri Enstitüsü, 2024-02-09)EROL DUYAR, Ö.D. Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives using Current Molecular Techniques and Technologies. Hacettepe University Graduate School of Health Sciences Stem Cell Doctor of ...