Browsing Nörolojik Bilimler ve Psikiyatri Enstitüsü by Rights "info:eu-repo/semantics/openAccess"
Now showing items 1-20 of 35
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12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke
(Lippincott Williams & Wilkins, 2017)Background and Purpose For stroke prevention, patients with atrial fibrillation typically receive oral anticoagulation. The commonly used anticoagulant warfarin increases the risk of hemorrhagic transformation (HT) when a ... -
Beyin Kökenli Nörotrofik Faktörün Kortikal Yayılan Depresyonun Tetiklediği Nöroinflamasyon Üzerine Etkilerinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-04)Cortical spreading depression (CSD) is not just an experimental phenomenon, but also seen in the conditions such as migraine aura, ischemic stroke, acute brain trauma, intracranial hemorrhage and epilepsy in people. It has ... -
Bilateral Temporal Bone Xanthomas in Type II Hypercholesterolemia
(Turkish Neurosurgical Soc, 2010)We present a very rare case of intracranial xanthoma with bilateral temporal bone involvement. The lesion caused destruction and remodelling in mastoid air cells. On the right side, cerebellar compression was obvious. The ... -
Capillary Pericytes Express Α-Smooth Muscle Actin, Which Requires Prevention of Filamentous-Actin Depolymerization For Detection
(eLife Sciences, 2018)Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, ... -
Çocukluk Çağı Epilepsi Hastalarında Erken Senesens Biyobelirteçleri ve Komorbid Bilişsel Etkilenme ile İlişkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-07-03)Senescence, a steady loss of proliferative capacity triggered by complex pathways, has been studied in neurodegenerative diseases but remains obscure in epilepsy. This study aims to investigate whether the chronic stress ... -
Data Of Ascending Cortical Vein Occlusion Induced Spreading Depression
(Elsevier, 2018)The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related ... -
Default Mode Network Connectivity Is Linked to Cognitive Functioning and Csf A Beta(1-42) Levels In Alzheimer'S Disease
(Elsevier Ireland Ltd, 2016)Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific A beta pathology. Methods: Cognitive profiles; DMN connectivity alterations; ... -
Deneysel İskemik İnme Modelinde Oksidatif Hasarın Hücresel Düzeyde İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-11)The aim of this study is direct intravital monitorization of the pharmacological effects of two well-known neuroprotectant antioxidant molecules having different blood-brain barrier (BBB) permeability against ischemia/reperfusion ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
DOPA Yanıtlı Distoni Fare Modelinde Striatal Kolinerjik Sistemin Rolü
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022-05-26)Dystonia, which is the third most common movement disorder, is a heterogeneous group of diseases both etiologically and pathophysiologically. Striatal cholinergic dysfunction is a common pathophysiologiccal mechanism ... -
Dysregulated Fibroblast Growth Factor (Fgf) Signaling in Neurological and Psychiatric Disorders
(Academic Press Ltd Elsevier Science Ltd, 2016)The role of the fibroblast growth factor (FGF) system in brain-related disorders has received considerable attention in recent years. To understand the role of this system in neurological and psychiatric disorders, it is ... -
Elektrokonvulzı̇f Nöbetlerı̇n Farelerde Nöroı̇nflamatuvar Yanıt Üzerı̇ndekı̇ Olası Etkı̇sı̇ ve Bu Etkı̇nı̇n Doğurduğu Sonuçların İncelenmesı̇
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2017)Neuroinflammation has been shown to be involved in pathological conditions like cortical spreading depression, seizures and ischemia. Its involvement in physiological processes like neurogenesis, learning and memory has ... -
Fare Ligaman Perforasyon SAK modelinde Squalene Adenozin Nanoparçaların Beyin Kan Akımı ve Nörolojik Skorlara Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)The aim of this study is to investigate the cerebral blood flow (CBF) changes in the first 24 hours following SAH, the effect of intravenous squalene-adenosine on CBF, functional outcome of mice and cerabral histologic ... -
Farede Optogenetik Yolla Tetiklenen Kortikal Yayılan Depresyonun Subkortikal Yayılım Mekanizmalarının İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)Uzay B. Investigation of the Subcortical Spreading Mechanisms of the Optogenetically Induced Cortical Spreading Depression in Mice, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis In Two Pairs Of Identical Twins
(Comenius Univ, 2012)The most common pathology in adult patients with temporal lobe epilepsy is hippocampal sclerosis (HS), the etiology of which is not clear. There is a conflicting evidence in literature regarding whether HS is genetic or ... -
Mitochondrial Dna Analysis in The Turkish Leber'S Hereditary Optic Neuropathy Population
(Royal Coll Ophthalmologists, 2001)Purpose To define the prevalence of a panel of mitochondrial DNA (mtDNA) mutations associated with Leber's hereditary optic neuropathy (LHON) in the Turkish LHON population. LHON-associated mtDNA mutations have been found ... -
Molecular Motor Contractıle Mechanısm of Retınal Perıcytes
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020)Although it is known that capillary pericytes function in the regulation of capillary tone and blood flow, the contractile proteins involved in these processes are unidentified. It is likely that α-SMA functions as a part ...