Browsing Nörolojik Bilimler ve Psikiyatri Enstitüsü by Title
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Fare Ligaman Perforasyon SAK modelinde Squalene Adenozin Nanoparçaların Beyin Kan Akımı ve Nörolojik Skorlara Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)The aim of this study is to investigate the cerebral blood flow (CBF) changes in the first 24 hours following SAH, the effect of intravenous squalene-adenosine on CBF, functional outcome of mice and cerabral histologic ... -
Farede Optogenetik Yolla Tetiklenen Kortikal Yayılan Depresyonun Subkortikal Yayılım Mekanizmalarının İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)Uzay B. Investigation of the Subcortical Spreading Mechanisms of the Optogenetically Induced Cortical Spreading Depression in Mice, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences ... -
Fizyolojik Uyarılarla Kortikal Yayılan Depresyonun Oluşturulması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2015)Migraine is a primary headache disorder with an annual prevalence of 12-15% in the general population, causing considerable disability and productivity loss. Migraine aura is associated with cortical spreading depression (CSD) ... -
Glikojen Döngüsünün Bozulmasının Kortikal Yayılan Depolarizasyon Oluşumu ve Panneksin 1 Kanalları Üzerine Etkisinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2013)Migraine is an episodic neurological disorder that affects 10-20 % of general population. Cortical spreading depression (CSD) is proposed as the mechanism of migraine aura and the downstream trigeminal activation as the ... -
Glikojenin İskemik İnme ve Retinal İskemi Üzerine Olan Etkilerinin Nörogliovasküler Seviyede İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020-01-16)Ischemic stroke results in sudden blood flow cessation thus leads to sudden onset unmet energy requirements. Although the clotted artery is recanalized and blood flow is restored back, brain perfusion may not be sustained ... -
Görsel, Motor ve Somatosensoriyel Korteks İntegrasyonunun Non-invazif Elektrofizyolojik Yöntemlerle Değerlendirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-03-25)Corticospinal excitability may be affected by various sensory inputs under physiological conditions. Studies about the connection and interaction between the primary motor cortex and these cortical sensory areas indicate ... -
Hücre Membranı Yamayıcı Molekülleri ile Panneksin1 Megakanalı Arasındaki Olası İlişkinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2015)For most of the neurological diseases, new theurapeutic targets and drugs are needed. During the last several years one of the large pore channels, Pannexin (Panx) channels have emerged as an important target for neurological ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis In Two Pairs Of Identical Twins
(Comenius Univ, 2012)The most common pathology in adult patients with temporal lobe epilepsy is hippocampal sclerosis (HS), the etiology of which is not clear. There is a conflicting evidence in literature regarding whether HS is genetic or ... -
Mitochondrial Dna Analysis in The Turkish Leber'S Hereditary Optic Neuropathy Population
(Royal Coll Ophthalmologists, 2001)Purpose To define the prevalence of a panel of mitochondrial DNA (mtDNA) mutations associated with Leber's hereditary optic neuropathy (LHON) in the Turkish LHON population. LHON-associated mtDNA mutations have been found ... -
Molecular Motor Contractıle Mechanısm of Retınal Perıcytes
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020)Although it is known that capillary pericytes function in the regulation of capillary tone and blood flow, the contractile proteins involved in these processes are unidentified. It is likely that α-SMA functions as a part ... -
Multipl Skleroz ve Parkinson Hastalarında Neopterin Düzeyi ve Kinürenin Yolağının İnflamasyon ve Nörodejenerasyon Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)ABSTRACT Yavas, I. The Effect of Neopterin Level and Kynurenine Pathway on Inflammation and Neurodegeneration in Patients with Multiple Sclerosis and Parkinson's. Hacettepe University Graduate School Health Sciences ... -
Mutation Analysis Of The Pink1 Gene In 391 Patients With Parkinson Disease
(Amer Medical Assoc, 2008)Objectives: To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations. Design: Retrospective clinical and genetic review. Setting: University hospital. Patients: We ... -
Mutations in A Human Robo Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis
(Amer Assoc Advancement Science, 2004)The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form ... -
Neuro-Ophthalmologic Findings In Humans With Quadrupedal Locomotion
(Informa Healthcare, 2012)Purpose: To report the neuro-ophthalmologic findings in four patients from the same family with cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ) 2 associated with quadrupedal locomotion. Method: ... -
Nuclear Expansion And Pore Opening Are Instant Signs Of Neuronal Hypoxia And Can Identify Poorly Fixed Brains
(Nature Publishing Group, 2018)The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal ... -
Optogenetik uyarımla nf-κb aktivasyonu yapan bir yöntemin mss'de inflamasyonun primer depresyon patofizyolojisindeki rolünün incelenmesi amacıyla ın vıvo koşullar için geliştirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-01-05)One of the critical limitations of the studies examining the effects of neuro-inflammation on depression is not implementing a protocol compatible with the pathophysiology of primary depression instead of using a protocol ... -
Otizm Spektrum Bozukluğunda Nöroinflamasyonun Sinaptik Plastiklik Üzerine Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-02-22)Ünal D. The Effects Of Neuroinflamation On Synaptic Plasticity In Autism Spectrum Disorders, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences (Neuroscience) Program, Doctor of ...