Başlık için Nörolojik Bilimler ve Psikiyatri Enstitüsü listeleme
Toplam kayıt 46, listelenen: 21-40
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Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis In Two Pairs Of Identical Twins
(Comenius Univ, 2012)The most common pathology in adult patients with temporal lobe epilepsy is hippocampal sclerosis (HS), the etiology of which is not clear. There is a conflicting evidence in literature regarding whether HS is genetic or ... -
Mitochondrial Dna Analysis in The Turkish Leber'S Hereditary Optic Neuropathy Population
(Royal Coll Ophthalmologists, 2001)Purpose To define the prevalence of a panel of mitochondrial DNA (mtDNA) mutations associated with Leber's hereditary optic neuropathy (LHON) in the Turkish LHON population. LHON-associated mtDNA mutations have been found ... -
Molecular Motor Contractıle Mechanısm of Retınal Perıcytes
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020)Although it is known that capillary pericytes function in the regulation of capillary tone and blood flow, the contractile proteins involved in these processes are unidentified. It is likely that α-SMA functions as a part ... -
Multipl Skleroz ve Parkinson Hastalarında Neopterin Düzeyi ve Kinürenin Yolağının İnflamasyon ve Nörodejenerasyon Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)ABSTRACT Yavas, I. The Effect of Neopterin Level and Kynurenine Pathway on Inflammation and Neurodegeneration in Patients with Multiple Sclerosis and Parkinson's. Hacettepe University Graduate School Health Sciences ... -
Mutation Analysis Of The Pink1 Gene In 391 Patients With Parkinson Disease
(Amer Medical Assoc, 2008)Objectives: To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations. Design: Retrospective clinical and genetic review. Setting: University hospital. Patients: We ... -
Mutations in A Human Robo Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis
(Amer Assoc Advancement Science, 2004)The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form ... -
Neuro-Ophthalmologic Findings In Humans With Quadrupedal Locomotion
(Informa Healthcare, 2012)Purpose: To report the neuro-ophthalmologic findings in four patients from the same family with cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ) 2 associated with quadrupedal locomotion. Method: ... -
Nuclear Expansion And Pore Opening Are Instant Signs Of Neuronal Hypoxia And Can Identify Poorly Fixed Brains
(Nature Publishing Group, 2018)The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal ... -
Optogenetik uyarımla nf-κb aktivasyonu yapan bir yöntemin mss'de inflamasyonun primer depresyon patofizyolojisindeki rolünün incelenmesi amacıyla ın vıvo koşullar için geliştirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-01-05)One of the critical limitations of the studies examining the effects of neuro-inflammation on depression is not implementing a protocol compatible with the pathophysiology of primary depression instead of using a protocol ... -
Otizm Spektrum Bozukluğunda Nöroinflamasyonun Sinaptik Plastiklik Üzerine Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-02-22)Ünal D. The Effects Of Neuroinflamation On Synaptic Plasticity In Autism Spectrum Disorders, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences (Neuroscience) Program, Doctor of ... -
Parenchymal Neuroinflammation in Familial Hemiplegic Migraine Type 1 Transgenic Mouse Model After Cortical Spreading Depression
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-01)Cortical spreading depression (CSD) is the likely cause of the migraine aura. CSD causes a signaling pathway between stressed neurons and trigeminal afferents via transient opening of neuronal Pannexin-1 (Panx1) mega-channels ... -
Pediyatrik ve Erişkin Hemofagositik Sendromların Tanı ve Tedavi Uygulamalarının Gözden Geçirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-09-27)Hemophagocytic syndromes are rare, life-threatening conditions characterized by hypercytokinemia, systemic inflammation, and overstimulation of the immune system leading to multi-organ failure. Primary Hemophagocytic ... -
Periferik Sinir Continous Teta Burst Stimülasyonunun (Periferik-cTBS) Kortikal Uyarılabilirlik Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-06-29)Panpallı Ateş, M., Effect of Peripheral Nerve Continuous Theta Burst Stimulation (“Peripheral-cTBS”) on Cortical Excitability, Hacettepe University Institute of Health Sciences -Advanced Neurological and Psychiatric Sciences ... -
Plasma Glycine and Serine Levels in Schizophrenia Compared to Normal Controls and Major Depression: Relation to Negative Symptoms
(Oxford Univ Press, 2004)Previous Studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, ... -
Prefrontal Kortekste NUDT6 İfadesindeki Değişikliklerin Sıçanda Depresyon-Benzeri ve Anksiyete-Benzeri Davranışa Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2018-06-12)Hökelekli, F.Ö. The Effects of NUDT6 Expression Changes in Prefrontal Cortex on Depression- and Anxiety-like Behaviour in Rats, Hacettepe University, Graduate School of Health Sciences PhD thesis in Basic Neurological ... -
Psikolojik Stres İle Kortikal Yayılan Depresyon Uyarılma Eşiği İlişkisi ve İlgili Mekanizmaları
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2013)Migraine is suggested to belinked to cortical spreading depression (CSD), thus CSD is used to model migraine inexperimental animals. Migraine is frequently comorbid with depression and anxiety,two disorders that are ... -
Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings
(Aves, 2016)Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been ...