Yayın tarihi için Nörolojik Bilimler ve Psikiyatri Enstitüsü listeleme
Toplam kayıt 46, listelenen: 21-40
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Capillary Pericytes Express Α-Smooth Muscle Actin, Which Requires Prevention of Filamentous-Actin Depolymerization For Detection
(eLife Sciences, 2018)Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, ... -
Data Of Ascending Cortical Vein Occlusion Induced Spreading Depression
(Elsevier, 2018)The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related ... -
Nuclear Expansion And Pore Opening Are Instant Signs Of Neuronal Hypoxia And Can Identify Poorly Fixed Brains
(Nature Publishing Group, 2018)The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Prefrontal Kortekste NUDT6 İfadesindeki Değişikliklerin Sıçanda Depresyon-Benzeri ve Anksiyete-Benzeri Davranışa Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2018-06-12)Hökelekli, F.Ö. The Effects of NUDT6 Expression Changes in Prefrontal Cortex on Depression- and Anxiety-like Behaviour in Rats, Hacettepe University, Graduate School of Health Sciences PhD thesis in Basic Neurological ... -
Fare Ligaman Perforasyon SAK modelinde Squalene Adenozin Nanoparçaların Beyin Kan Akımı ve Nörolojik Skorlara Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)The aim of this study is to investigate the cerebral blood flow (CBF) changes in the first 24 hours following SAH, the effect of intravenous squalene-adenosine on CBF, functional outcome of mice and cerabral histologic ... -
Farede Optogenetik Yolla Tetiklenen Kortikal Yayılan Depresyonun Subkortikal Yayılım Mekanizmalarının İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)Uzay B. Investigation of the Subcortical Spreading Mechanisms of the Optogenetically Induced Cortical Spreading Depression in Mice, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences ... -
Parenchymal Neuroinflammation in Familial Hemiplegic Migraine Type 1 Transgenic Mouse Model After Cortical Spreading Depression
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-01)Cortical spreading depression (CSD) is the likely cause of the migraine aura. CSD causes a signaling pathway between stressed neurons and trigeminal afferents via transient opening of neuronal Pannexin-1 (Panx1) mega-channels ... -
Görsel, Motor ve Somatosensoriyel Korteks İntegrasyonunun Non-invazif Elektrofizyolojik Yöntemlerle Değerlendirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-03-25)Corticospinal excitability may be affected by various sensory inputs under physiological conditions. Studies about the connection and interaction between the primary motor cortex and these cortical sensory areas indicate ... -
Beyin Kökenli Nörotrofik Faktörün Kortikal Yayılan Depresyonun Tetiklediği Nöroinflamasyon Üzerine Etkilerinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-04)Cortical spreading depression (CSD) is not just an experimental phenomenon, but also seen in the conditions such as migraine aura, ischemic stroke, acute brain trauma, intracranial hemorrhage and epilepsy in people. It has ... -
Deneysel İskemik İnme Modelinde Oksidatif Hasarın Hücresel Düzeyde İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-11)The aim of this study is direct intravital monitorization of the pharmacological effects of two well-known neuroprotectant antioxidant molecules having different blood-brain barrier (BBB) permeability against ischemia/reperfusion ... -
Molecular Motor Contractıle Mechanısm of Retınal Perıcytes
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020)Although it is known that capillary pericytes function in the regulation of capillary tone and blood flow, the contractile proteins involved in these processes are unidentified. It is likely that α-SMA functions as a part ... -
Glikojenin İskemik İnme ve Retinal İskemi Üzerine Olan Etkilerinin Nörogliovasküler Seviyede İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020-01-16)Ischemic stroke results in sudden blood flow cessation thus leads to sudden onset unmet energy requirements. Although the clotted artery is recanalized and blood flow is restored back, brain perfusion may not be sustained ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
DOPA Yanıtlı Distoni Fare Modelinde Striatal Kolinerjik Sistemin Rolü
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022-05-26)Dystonia, which is the third most common movement disorder, is a heterogeneous group of diseases both etiologically and pathophysiologically. Striatal cholinergic dysfunction is a common pathophysiologiccal mechanism ... -
Yetersiz Perisinaptik Astrosit Glikojeni Kullanımının Nöroinflamatuvar ve Davranışsal Etkilerinin İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)Several findings suggest that the brain energy demand is mostly localized at the synapses, and glycogen in the perisynaptic astrocytic endfeet serves as the main actor that matches the synaptic energy supply and demand. ... -
Multipl Skleroz ve Parkinson Hastalarında Neopterin Düzeyi ve Kinürenin Yolağının İnflamasyon ve Nörodejenerasyon Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)ABSTRACT Yavas, I. The Effect of Neopterin Level and Kynurenine Pathway on Inflammation and Neurodegeneration in Patients with Multiple Sclerosis and Parkinson's. Hacettepe University Graduate School Health Sciences ... -
The Investigation the Role of Reduced Folate Carrier 1 in the Models of Ischemic Stroke and Retinal Ischemia
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)Gurler, G., The Investigation the Role of Reduced Folate Carrier 1 in the Models of Ischemic Stroke and Retinal Ischemia, Hacettepe University, Graduate School of Health Sciences, Neuroscience Program, Doctor of Philosophy ...