Başlık için Kanser Enstitüsü listeleme
Toplam kayıt 110, listelenen: 93-110
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Tamoxifen-Induced Tissue Factor Pathway Inhibitor Reduction: A Clue for an Acquired Thrombophilic State?
(Oxford Univ Press, 2004)Background: Current understanding of hemostatic systems enables us to better explore the enigmatic pathobiology of tamoxifen (TAM)-induced thrombotic diathesis. We have therefore aimed to assess the hemostatic changes in ... -
Targeted Therapies in Gastric Cancer and Future Perspectives
(Baishideng Publishing Group Inc, 2016)Advanced gastric cancer (AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research ... -
The Association Between Body Mass Index and Immunohistochemical Subtypes in Breast Cancer
(Elsevier, 2017)Background:Body mass index (BMI) is defined as a poor prognostic factor in patients with breast cancer(BC). However, there are controversial results regarding the various effects of BMI on BC, hence the exactpathophysiology ... -
The Effect of Acute Myeloid Leukemia Cells Expressing PD-L2 Co-Stimulatory Molecule on Helper T Cell Activation
(Sağlık Bilimleri Enstitüsü, 2017-07-25)The binding of PD-1 to its ligands (PD-L1 and PD-L2) inhibits and/or regulates T cell responses. Myeloid leukemia cells can express both co-activatory and co-inhibitory molecules simultaneously. The function of PD-L1 in ... -
The Effect of Inducıble Costımulatory Lıgand (Icos-Lg) Expressıng Myeloıd Leukemıa Cells on Helper T Lymphocyte Actıvatıon and Exhaustıon
(Kanser Enstitüsü, 2015)T cell exhaustion is characterized by progressive loss of cytokine production, decreased proliferation and resistance to reactivation especially upon continuous antigen stimulation. Despite being potent stimulators of ... -
The Effects of Tumor Mıcroenvironment on T Cell Responses in a Rat Chemical Mammary Carcinoma Model
(Kanser Enstitüsü, 2013)The studies that have investigated the nature of the cells and molecules responsible for the functional insufficiency of the tumor infiltrating T cells usually on several components; however, the contribution of stromal ... -
The Relationship of Agmatine Deficiency with the Lung Cancer
(Akad Doktorlar Yayınevi, 2016)The polyamines are essential for rapidly growing cells. Polyamines is synthesized by two reactions which begin from arginine. The aim of this study is to examine the serum levels of the enzymes located in the putrescine ... -
The Role of Regnase-1 Protein in Sculpting of Tumor Microenvironment
(Kanser Enstitüsü, 2021)The tumor microenvironment (TME) contains cancer-associated fibroblasts (CAFs) and their tumor-supportive role helps to build an environment in favor of cancer cell progression. Recent researches have revealed that targeting ... -
Tip-1 Yardımcı T (Th1) Hücrelerin Radyasyon Stresi Altında Fonksiyonel ve Fenotipik Değişimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022-07-18)It's critical to understand changes in the functional and phenotypic status of T cells, which play a key role in the anti-tumor response due to the immunosuppressive environment in the tumor microenvironment. In chronic ... -
Transfection of Myeloid Leukaemia Cell Lines Is Distinctively Regulated By Fibronectin Substratum
(Springer, 2009)Gene transfer into haematopoietic cells is a challenging approach. The extracellular matrix component fibronectin has been known to modulate the cell cycle dynamics, viability and differentiation of leukaemia cells. Thus, ... -
Tüm Beden Işınlamalarında Farklı Tedavi Planlama Tekniklerinin Dozimetrik Olarak Karşılaştırılması
(Kanser Enstitüsü, 2021-02-10)The purpose of Total Body Irradiation (TBI) in radiotherapy is to suppress the immune system of the patient by destroying bone marrow cells, prepare the host for bone marrow transplantation and enhance the antitumor effect. ... -
Ubiquitination And Regulation Of Aurka Identifies A Hypoxia-Independent E3 Ligase Activity Of Vhl
(Nature Publishing Group, 2017)The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor α (HIFα) being ... -
Vaccination Attitudes Among Patients With Cancer Receiving Chemotherapy
(Akad Doktorlar Yayınevi, 2016)Immunization against vaccine preventable diseases is an essential but mostly overlooked issue in oncology practice. We aimed to investigate the utilization of adult immunization recommendations and the perception of the ... -
Vajinal Kaf Brakiterapi Uygulamaları için Yoğunluk Ayarlı Aplikatör Tasarımı: Dozimetrik Fizibilite Çalışması
(Kanser Enstitüsü, 2018)Depending on technological advances in radiotherapy, the use of three-dimensional (3D) treatment planning in brachytherapy (BRT) applications has provided a great advantage in terms of efficacy of treatment in gynecological ... -
Vulva Kanserinde Elektron-YART Hibrit Tedavi Modalitesinin Tedavi Planlama Sistemi ve Dozimetrik Yöntemlerle İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-02-20)In recent years, in the treatment of vulvar cancer, intensity modulated radiation therapy (IMRT) have been used instead of 3 dimensional conformal radiotherapy (3DCRT). In this thesis study, 7 patients who were diagnosed ... -
Vücut Içerisindeki Doku Eşdeğeri Olmayan Implant Materyallerinin Yoğunluk Ayarlı Radyoterapi ve Stereotaktik Radyocerrahi Tedavilerinde Doz Dağılımına Etkisinin İncelenmesi
(Kanser Enstitüsü, 2015)Several cancer patients, who have implant and filling material in their body, are treated with radiotherapy and those materials may cause dosimetric uncertainities during treatment which may not be estimated accurately by ... -
Yoğunluk Ayarlı Radyoterapi Tekniğinde İn Vivo Dozimetri İçin Elektronik Portal Görüntüleme Sistemi ve Diyot Dedektörlerin Kullanılması
(Kanser Enstitüsü, 2013)Intensity Modulated Radiation Therapy (IMRT) is an advanced method of three-dimensional conformal radiotherapy techniques. Patient-specific quality assurances are very important for IMRT technic. These assurances are often ... -
Β-Catenın N-Terminal Bölge Değişikliklerinin Neoplastik Süreçlerdeki Rolünün Araştırılması
(Kanser Enstitüsü, 2021)Uzun, S, Investigation of The Role of β-catenin N-terminal Domain Alterations in Neoplastic Processes, Hacettepe University Graduate School of Health Sciences Tumor Biology and Immunology Program Doctor of Philosophy ...