Dosya Biçimi"TÜBİTAK" Enstitüler için listeleme
Toplam kayıt 44, listelenen: 1-20
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Akut myeloblastik lösemi (aml) hastalığı hücrelerinin aptamer temelli akım sitometrik profillenmesi
(Sağlık Bilimleri Enstitüsü, 2023-02)AKCA O, Aptamer Based Flow Cytometric Profiling in Acute Myeloblastic Leukemia (AML) Disease Cells. Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2023. Aptamers are short, ... -
Allojenik Mezenkimal Kök Hücreler ve Mikroakışkan Sistemle Vücut Dışında Testisteki Spermatogonyal Kök Hücre Mikroçevresinin Devamlılığının Sağlanması
(Sağlık Bilimleri Enstitüsü, 2023)Chemoradiotherapeutics used in childhood cancers result in permenant infertility in half of male patients. Bone marrow derived mesenchymal stem cells (BMMSC) share some of their secretomes and their embryonic origin with ... -
Alt-Birim Protein Antijenlerinin İmmunojenitesini Artırmak Amacıyla Yeni Adjuvant/Taşıyıcı Sistemlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-07-22)Infectious diseases encompass 25% of deaths in the world per year. The most effective approach in preventing deaths is vaccination. However, at present, the availability of vaccines for many infectious diseases is still ... -
Alzheimer Hastalığında serum proteomik analizleri ile yeni biyobelirteçlerin araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024)Current diagnostic criteria set for Alzheimer’s Disease (AD) is not sufficient for accurate prediction of the pathology. The use of CSF and PET biomarkers increase the accuracy of diagnoses but they are limited for widespread ... -
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ... -
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Comparatıve Analysıs of Myeloıd-Derıved Suppressor Cells From Blood and Spleen in Gastrıc and Pancreatıc Cancer
(Sağlık Bilimleri Enstitüsü, 2022-07-29)Under physiological conditions, development and maturation of the myeloid cells take place in the bone marrow. In case of chronic inflammatory disorders such as cancer, production of chemokines, growth factors, and cytokines ... -
Cyberknife® ve Varian RapidArc® TrilogyTM Cihazında Üç Boyutlu Uzaysal Fraksiyone Grid Terapi Doz Karakteristiklerinin Karşılaştırılması
(Kanser Enstitüsü, 2020-12). Lattice therapy is an innovative method to increase the effectiveness of radiotherapy by delivering a high dose to the target volume irradiated through small spaces in one or more fractions.In this study, we investigated ... -
Deselülerize Miyokard-Elastomer Yamaların Hazırlanması ve In Vitro Performanslarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)Heart failure is the final stage of most cardiovascular diseases, such as myocardial infarction. Unlike other tissues such as bone and skin, heart tissue does not have the ability to regenerate and repair itself. This ... -
Development of Jak1 Sirna Medıated Nanotherapeutıcs for Non-Melanoma Skın Cancer Therapy
(Fen Bilimleri Enstitüsü, 2021-06)Non-melanoma skin cancer is one of the most common cancers with still no effective treatment. Due to the side effects observed after long and high dose treatments and acquired resistance to the chemotherapy drugs, different ... -
Development of Karagöz the Shadow Puppetry in Virtual Reality Environment
(Bilişim Enstitüsü, 2023)In this era of technological advancements, the landscape of entertainment has undergone a transformative shift, leaving behind traditional forms in favor of new ones. While the judgment of whether this change is beneficial ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
Fenilketonüri Hastalığının Erken Teşhisi ve Takibi için Disk Tabanlı Hasta Başı Tanı Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-12)Phenylketonuria (PKU) is an autosomal recessive metabolic disease due to dysfunction of phenylalanine hydroxylase (PAH) enzyme, which converts phenylalanine (Phe) amino acid to tyrosine amino acid. Phe amino acid and ... -
Fonksiyonel Pet Nano Fiberlerin Üretilmesi ve Yara Örtüsü Olarak Kullanmak Üzere Modifiye Edilmiş Pet Fiberlere Protein Kaplı Gümüş Nanoparçacıkların Adsorpsiyonu
(Fen Bilimleri Enstitüsü, 2020)In this study, silver nanoparticles (S-AgNPs) coated with sericin were adsorbed on poly (ethylene terephthalate)-g-poly(hydroxyethylmethacrylate) (PET-g-HEMA) nanofibres and the use of the obtained material as wound dressing ... -
Fotovoltaik Uygulamalar için CZTS (Cu2SnZnS4) İnce Filmlerin Sentezi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2022)Today, thin-film-based photovoltaic (PV) structures attract attention in the search for alternatives to Si-based solar cells. Among the thin films, the Cu2ZnSnS4 (CZTS) compound is the most remarkable with its optical and ... -
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ... -
Heterojen Biyomedikal Verinin Bilgi Çizgeleri ve Derin Öğrenme Tabanlı Analizi ile Protein Fonksiyonlarının Otomatik Tahmini
(Sağlık Bilimleri Enstitüsü, 2023-07-31)Proteins are vital for cellular processes, and accurately determining their functions is crucial for understanding complex biological mechanisms. Computational approaches have emerged as alternatives to expensive and ... -
Hipoksinin Anti-Tümor İmmün Yanıt Üzerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Inhibition of tumor angiogenesis has been extensively utilized in the treatment of metastatic colorectal cancer and renal cell carcinoma. Complete disruption of tumor angiogenesis results in hypoxia which promotes tumor ... -
Hücresizleştirilmiş Sığır Gözü Kası ve Pclkas Matriksi Kompozit Doku İskeleleriyle Göz Kası Rejenerasyonu
(Fen Bilimleri Enstitüsü, 2021)This study has been financially supported by TÜBİTAK under the project named "Extraocular Muscle Regeneration by Decellurized Bovine Extraocular Muscle and PCL-Extraocular Muscle Matrix Composite Tissue Skeleton" (1002 ...