Konu "T-Dm1" için listeleme

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Targeting Plk1 Overcomes T-Dm1 Resistance Via Cdk1-Dependent Phosphorylation and Inactivation Of Bcl-2/Xl in Her2-Positive Breast Cancer

Saatçi, Özge; Borgoni, Simone; Akbulut, Özge; Durmuş, Selvi; Raza, Umar; Eyüpoğlu, Erol; Alkan, Can; Akyol, Aytekin; Kütük, Özgür; Wiemann, Stefan; Şahin, Özgür (Nature Publishing Group, 2018)

Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the microtubule-targeting ...